{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:48:15Z","timestamp":1781862495040,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of fluoride\u2010free mouthwashes (FFM) can adversely affect the anticaries benefits of fluoride toothpaste.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated (i) the impact of FFM on the anticaries benefits of fluoride toothpaste and (ii) differences in enamel\u2010lesion assessment between two TMR techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The study followed a 2 (technique) \u00d7\u20092 (toothpaste) \u00d7\u20094 (mouthwash) factorial design. Toothpaste (1100\u2009ppm\u2009F) contained either NaF or SnF<jats:sub>2<\/jats:sub>. Mouthwashes contained CPC or EOs. Control mouthwashes were DIW and not washed after toothpaste. Two TMR techniques, conventional specimens and single sections of enamel (<jats:italic>n<\/jats:italic>\u2009=\u20098), were utilized. During the 5\u2010day\/pH cycling, the specimens with artificial caries\u2010like lesions were treated two times\/day with toothpaste\/1\u2009min, followed by mouthwash\/30s. There was a 4\u2009h demineralization\/day. Integrated mineral loss (\u0394\u0394Z) and lesion depth (\u0394L) were determined. Data were analyzed using three\u2010way ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant interaction between the three factors for \u0394\u0394Z (<jats:italic>p<\/jats:italic>\u2009=\u20090.894) or \u0394L (<jats:italic>p<\/jats:italic>\u2009=\u20090.410) and no difference between toothpaste for \u0394\u0394Z (<jats:italic>p<\/jats:italic>\u2009=\u20090.977) or \u0394L (<jats:italic>p<\/jats:italic>\u2009=\u20090.507). However, mouthwashes affected \u0394\u0394Z and \u0394L (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The non\u2010wash group resulted in the most remineralization. The technique did not affect \u0394\u0394Z (<jats:italic>p<\/jats:italic>\u2009=\u20090.973).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fluoride\u2010free mouthwashes may decrease the remineralization potential of fluoride toothpaste, and the single\u2010section technique is a suitable alternative in caries research. Pediatric dentists can emphasize proper hygiene and parental guidance in supervising children's brushing\/rinsing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ipd.13315","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T06:00:22Z","timestamp":1745560822000},"page":"993-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevention of Dental Demineralization by Fluoride Toothpastes Followed by Fluoride\u2010Free Mouthwashes: A <scp>TMR<\/scp>\u2010D Conventional and Single\u2010Section Technique Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-501X","authenticated-orcid":false,"given":"Astrid Carolina","family":"Valdivia\u2010Tapia","sequence":"first","affiliation":[{"name":"Department of Biomedical and Applied Sciences Indiana University School of Dentistry  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Takeo","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Applied Sciences Indiana University School of Dentistry  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lippert","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Applied Sciences Indiana University School of Dentistry  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007868.pub3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002781.pub2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000239753"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000261456"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016540"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4810022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760091101"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660110801"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690010801"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345920710030401"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203459207100S27"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2023.104601"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12751"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010015\u20101436\u20101"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000261059"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374940080020601"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000261354"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj10010006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345610400061401"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111743"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100722.2009.00647.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444537"},{"key":"e_1_2_10_24_1","first-page":"32B","article-title":"Anticaries Potential of a Stabilized Stannous\u2010Containing Sodium Fluoride Dentifrice","volume":"23","author":"Faller R. 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