{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:24:02Z","timestamp":1786119842811,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of molar\u2010incisor hypomineralisation (MIH) has garnered increasing attention, with a likely association to hypomineralised second primary molars (HSPM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To elucidate the prevalence of MIH and its association with HSPM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This retrospective observational study combined repeated cross\u2010sectional analyses with a retrospective longitudinal cohort analysis of over 70\u2009000 children (851\u2009685 observations) attending public schools in Zurich, Switzerland (2005\u20132019). Hypomineralised lesions in second primary and first permanent molars were assessed. Prevalence rates and sex differences were calculated using annual age\u2010specific cross\u2010sectional samples. Logistic and log\u2010binomial regressions complemented by machine learning algorithms explored the longitudinal association between HSPM and MIH in children with records both at ages 5\u20137 and \u2265\u20098.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HSPM prevalence in five\u2010year\u2010olds increased from 5% to 13% between 2005 and 2019. Hypomineralised permanent first molars in eight\u2010year\u2010olds increased from 12% to 21%. Children with HSPM were approximately twice as likely to develop hypomineralised permanent molars (OR\u2009=\u20092.3; 95% CI: 2.1\u20132.5; PR\u2009=\u20091.9; 95% CI: 1.7\u20132.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large dataset confirms increasing HSPM and MIH diagnosis in Zurich between 2005 and 2019 and supports HSPM as a useful clinical indicator for elevated MIH risk. Limitations include study retrospectivity and potential examiner variability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ipd.70110","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:36:29Z","timestamp":1783326989000},"page":"715-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increasing Diagnosis of Enamel Hypomineralisation in a Sample of More Than 70\u2009000 Children in the City of Zurich: Repeated Cross\u2010Sectional Prevalence Analyses and a Retrospective Longitudinal Cohort Analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7601-7852","authenticated-orcid":false,"given":"Timo","family":"Saxer","sequence":"first","affiliation":[{"name":"Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Gharaviroudsari","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Diener","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-700X","authenticated-orcid":false,"given":"Daniel","family":"Wiedemeier","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100528.1987.tb00538.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047479"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495848"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u2010263x.2000.00210.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512440450"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u2010263X.2012.01223.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677\u201032252013000400011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010015\u20100190\u2010z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31929"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000135674"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12089"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010021\u201000646\u2010x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12579"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12323"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.23804\/ejpd.2019.20.01.12"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010017\u20102150\u2010y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010023\u201003637\u20100"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010022\u201004648\u2010x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.12.002"},{"issue":"3","key":"e_1_2_11_21_1","first-page":"110","article-title":"Judgement Criteria for Molar Incisor Hypomineralisation (MIH) in Epidemiologic Studies: A Summary of the European Meeting on MIH Held in Athens, 2003","volume":"4","author":"Weerheijm K. 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