{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:27:30Z","timestamp":1786595250926,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Paed Dentistry"],"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Children with more caries in the primary dentition have been observed to have greater caries risk in the permanent dentition. In a previous trial, we determined lesion arrest in primary teeth, where 38% SDF gel and 2.5% NaF varnish were applied sequentially. This follow\u2010up study determined the prevalence of children with any caries in untreated first permanent molars.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n The design was a retrospective cohort. Participants were drawn from five Centros Educativos Iniciales, Puno, Peru. Examinations were conducted 19\u2009months after the second treatment. Any caries prevalence (D\n 2\u20134<\/jats:sub>\n MFS >\u20090) and D\n 2\u20134<\/jats:sub>\n MFS were compared between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The exposed group was 219 children in the initial trial; the unexposed group was in the same classes but did not participate. 181\/237 (76.4%) children treated at baseline were followed up; 104 unexposed children were examined. Prevalence of any caries in first permanent molars was lower in exposed children (4.4%, 95% CI 1.4, 10) compared to unexposed (66.6%, 95% CI 53.6, 77.2;\n p<\/jats:italic>\n \u2009<\u20090.001). D\n 2\u20134<\/jats:sub>\n MFS in first permanent molars was lower in the exposed (median [IQR]\u2009=\u20090 [0, 0]) vs. unexposed (median [IQR]\u2009=\u20091 [0, 3];\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Children who received two sequential applications of SDF gel\/NaF varnish at 3\u20134y were observed to have fewer caries in first permanent molars at 6\u20137\u2009y than unexposed children.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ipd.70139","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:38:31Z","timestamp":1786592311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dental Caries in Permanent Molars of Children Previously Treated With Silver Fluoride Gel\/Sodium Fluoride Varnish in Their Primary Dentition: A Retrospective Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-1417","authenticated-orcid":false,"given":"Tania Carola Padilla","family":"C\u00e1ceres","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Universidad Nacional del Altiplano Puno Puno Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-3520","authenticated-orcid":false,"given":"Jorge Luis","family":"Castillo","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidad Peruana Cayetano Heredia Lima Peru"},{"name":"School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-207X","authenticated-orcid":false,"given":"Claudia Mariela Vera","family":"Reyes","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-3222","authenticated-orcid":false,"given":"Marilynn","family":"Rothen","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-8883","authenticated-orcid":false,"given":"Lloyd L.","family":"Mancl","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-9181","authenticated-orcid":false,"given":"Peter","family":"Milgrom","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.adaj.2024.02.013","article-title":"Using Sequential Applications of a Novel Silver Diamine Fluoride Gel and Sodium Fluoride Varnish to Arrest Severe Early Childhood Caries Lesions: A Clinical Trial With Single Group Assignment","volume":"155","author":"Padilla C\u00e1ceres T. C.","year":"2024","journal-title":"Journal of the American Dental Association"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2024.1492762","article-title":"The Role of Silver Diamine Fluoride as a Dental Caries Preventive and Arresting Agent: A Systematic Review and Meta\u2010Analysis","volume":"5","author":"Alqalaleef S. S.","year":"2024","journal-title":"Frontiers in Oral Health"},{"issue":"8","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/0022034512452278","article-title":"Randomized Trial on Fluorides and Sealants for Fissure Caries Prevention","volume":"91","author":"Liu B. Y.","year":"2012","journal-title":"Journal of Dental Research"},{"issue":"11","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/0810767","article-title":"Effectiveness of Silver Diamine Fluoride and Sodium Fluoride Varnish in Arresting Dentin Caries in Chinese Pre\u2010School Children","volume":"81","author":"Chu C. H.","year":"2002","journal-title":"Journal of Dental Research"},{"issue":"2","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/0022034517728496","article-title":"Randomized Clinical Trial of 12% and 38% Silver Diamine Fluoride Treatment","volume":"97","author":"Fung M. H. T.","year":"2018","journal-title":"Journal of Dental Research"},{"issue":"3","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-263X.2006.00720.x","article-title":"The Relationship Between Caries in the Primary Dentition at 5\u2009Years of Age and Permanent Dentition at 10\u2009Years of Age\u2014A Longitudinal Study","volume":"16","author":"Skeie M. S.","year":"2006","journal-title":"International Journal of Paediatric Dentistry"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep09555","article-title":"Antibacterial Activity of Silver\u2010Killed Bacteria: The \u201cZombies\u201d Effect","volume":"5","author":"Wakshlak R. B.","year":"2015","journal-title":"Science Reports"},{"issue":"6","key":"e_1_2_11_9_1","first-page":"469","article-title":"Associations Between Dental Treatment in the Primary and Permanent Dentitions Using Insurance Claims Data","volume":"22","author":"Heller K. E.","year":"2000","journal-title":"Pediatric Dentistry"},{"issue":"1","key":"e_1_2_11_10_1","article-title":"Dentin Tubule Occlusion by a 38% Silver Diamine Fluoride Gel: An Invitro Investigation","volume":"8","author":"Kiesow A.","year":"2022","journal-title":"British Dental Journal Open"},{"key":"e_1_2_11_11_1","volume-title":"Oral Health Surveys: Basic Methods","author":"World Health Organization","year":"2013"},{"issue":"4","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/jphd.12102","article-title":"Examination Criteria and Calibration Procedures for Prevention Trials of the Early Childhood Caries Collaborating Centers","volume":"75","author":"Warren J. J.","year":"2015","journal-title":"Journal of Public Health Dentistry"},{"key":"e_1_2_11_13_1","volume-title":"Generalized Estimating Equations","author":"Hardin J. W.","year":"2003"},{"key":"e_1_2_11_14_1","volume-title":"Introduction to Regression Methods for Public Health Using R","author":"Nahhas R. W.","year":"2025"},{"key":"e_1_2_11_15_1","unstructured":"C. H.Chu Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel ClinicalTrials.gov ID NCT06241261 Updated 2026\u201003\u201005 accessed August 9 2026 https:\/\/clinicaltrials.gov\/study\/NCT06241261."}],"container-title":["International Journal of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.70139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ipd.70139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ipd.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:38:34Z","timestamp":1786592314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ipd.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":14,"alternative-id":["10.1111\/ipd.70139"],"URL":"https:\/\/doi.org\/10.1111\/ipd.70139","archive":["Portico"],"relation":{},"ISSN":["0960-7439","1365-263X"],"issn-type":[{"value":"0960-7439","type":"print"},{"value":"1365-263X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ipd.70139"}}