{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:47:01Z","timestamp":1782798421333,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T00:00:00Z","timestamp":1358812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30972163"],"award-info":[{"award-number":["30972163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30571398"],"award-info":[{"award-number":["30571398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Cheung Kong Scholars and Innovative Research Team in University of China","award":["IRT0866"],"award-info":[{"award-number":["IRT0866"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute lung injury is an important cause of death in humans infected with H5N1. It has been found that oxygen free radicals (OFRs) are elevated in lung tissue during influenza virus infections. In this study, we used a mouse model to explore the role of OFRs in acute lung injury caused by H5N1 viral infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four\u2010 to six\u2010week\u2010old male specific pathogen\u2010free BALB\/c mice were inoculated intranasally with 10<jats:sup>5<\/jats:sup> 50% tissue culture infective doses (TCID<jats:sub>50<\/jats:sub>) of highly pathogenic A\/Chicken\/Hebei\/108\/2002 (H5N1) viruses and were then given 1000\u00a0IU of lauric acid modified superoxide dismutase (LA\u2010SOD) by intraperitoneal injection, starting 2\u00a0days post\u2010infection and continuing for 6\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The extent of lung injury and the concentration of OFRs were higher, and the SOD activity was lower in H5N1 virus\u2010infected mice than that in uninfected control mice on days 3, 6, and 7 post\u2010inoculation. Weak amelioration of clinical signs, a minor decrease in the total mortality and the extent of lung injury, and the lower OFRs concentration were seen in the LA\u2010SOD treatment group, but a reduction in lung virus titers was not observed in the LA\u2010SOD treatment at all time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LA\u2010SOD treatment has a mild inhibitory effect on H5N1 influenza virus infection in mice. OFRs, therefore, might play an important role in the pathogenesis of acute lung injury induced by H5N1 virus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12067","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T08:30:40Z","timestamp":1358843440000},"page":"945-953","source":"Crossref","is-referenced-by-count":22,"title":["Oxygen free radical involvement in acute lung injury induced by H5N1 virus in mice"],"prefix":"10.1111","volume":"7","author":[{"given":"Guimei","family":"He","sequence":"first","affiliation":[{"name":"Department of Pathophysiology College of Veterinary Medicine China Agricultural University Beijing China"},{"name":"Institute of Molecular Ecology and Evolution Institutes for Advanced Interdisciplinary Research, East China Normal University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology College of Veterinary Medicine China Agricultural University Beijing China"},{"name":"Panjin Animal Disease Control Center Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn M.","family":"McAllan","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Discipline of Physiology Medical Foundation Building (K25) The University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Animal Science, HeBei North University Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.Cumulative number of confirmed human cases of avian influenza A (H5N1) reported to WHO 2003\u20102011. 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