{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:34:35Z","timestamp":1792157675570,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To ascertain the full mortality of influenza and other respiratory viruses, the testing of community autopsy specimens is essential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Respiratory virus <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and culture were performed on 2418 fresh unfrozen respiratory samples collected from 1611 coronial cases where the death was either unknown or infection was suspected, from July 2007 to June 2011, to detect the common respiratory viruses in children and adults, using standardized microbiological testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The respiratory virus positive rate was 8\u00b73% (134 cases) with a peak of 28% (42 of 151 cases) in children under 10\u00a0years of age. Influenza virus was the commonest respiratory virus (50 cases, 3%), followed by respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>) (30 cases, 2%). All tested respiratory viruses were found in children, most commonly adenovirus, enterovirus and <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>, and influenza <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> predominated in those over 60\u00a0years, but coinfection was uncommon. Almost all influenza cases occurred when influenza was widely circulating in the community but few were diagnosed pre\u2010mortem. Influenza and <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> detection was associated with bronchitis or bronchiolitis in 7 (9%) of the 80 cases and caused pneumonia in 14 (0\u00b78%) deaths overall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our prospective review of respiratory viruses using standardized testing found a single lower respiratory tract autopsy specimen for respiratory virus <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> would detect most community infections at the time of death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12139","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T09:12:56Z","timestamp":1373965976000},"page":"1113-1121","source":"Crossref","is-referenced-by-count":17,"title":["Influenza and respiratory syncytial virus are the major respiratory viruses detected from prospective testing of pediatric and adult coronial autopsies"],"prefix":"10.1111","volume":"7","author":[{"given":"David J.","family":"Speers","sequence":"first","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Queen Elizabeth II Medical Centre Nedlands WA Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia Crawley WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Forensic Pathology PathWest Laboratory Medicine WA Queen Elizabeth II Medical Centre Nedlands WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Minney\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Queen Elizabeth II Medical Centre Nedlands WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avram","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Queen Elizabeth II Medical Centre Nedlands WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Queen Elizabeth II Medical Centre Nedlands WA Australia"},{"name":"School of Pathology and Laboratory Medicine University of Western Australia Crawley WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta14550-02"},{"key":"e_1_2_7_3_1","first-page":"1479","article-title":"Pandemic (H1N1) 2009\u2013associated deaths detected by unexplained death and medical examiner surveillance","volume":"17","author":"Lees CH","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00193939"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-003-0367-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-010-9181-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200105000-00005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-8-122"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2010.09.004"},{"key":"e_1_2_7_10_1","first-page":"S13","article-title":"Occult respiratory viral infections in coronial autopsies: a pilot project","volume":"15","author":"Nicholls JM","year":"2009","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01435-09"},{"key":"e_1_2_7_12_1","first-page":"374","volume-title":"Diagnostic Molecular Microbiology, Principles and Applications","author":"Zhang W","year":"1993"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.08.002"},{"key":"e_1_2_7_14_1","unstructured":"Australian Bureau of Statistics.Deaths Australia 2011. 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