{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:57:14Z","timestamp":1790683034770,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,10]],"date-time":"2013-11-10T00:00:00Z","timestamp":1384041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Published data on influenza in severe acute respiratory infection (<jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content>) patients are limited. We conducted <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> surveillance in central China and estimated hospitalization rates of <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> attributable to influenza by viral type\/subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surveillance was conducted at four hospitals in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ingzhou, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina from 2010 to 2012. We enrolled hospitalized patients who had temperature \u226537\u00b73\u00b0C and at least one of: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. A nasopharyngeal swab was collected from each case\u2010patient within 24\u00a0hours of admission for influenza testing by real\u2010time reverse transcription <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 17\u00a0172 <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> patients enrolled, 90% were aged &lt;15\u00a0years. The median duration of hospitalization was 5\u00a0days. Of 16\u00a0208 (94%) <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> cases tested, 2057 (13%) had confirmed influenza, including 1427 (69%) aged &lt;5\u00a0years. Multiple peaks of influenza occurred during summer, winter, and spring months. Influenza was associated with an estimated 115 and 142 <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> hospitalizations per 100\u00a0000 during 2010\u20132011 and 2011\u20132012 [including A(H3N2): 55 and 44 <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> hospitalizations per 100\u00a0000; pandemic A(H1N1): 33 <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> hospitalizations per 100\u00a0000 during 2010\u20132011; influenza <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>: 26 and 98 hospitalizations per 100\u00a0000], with the highest rate among children aged 6\u201311\u00a0months (3603 and 3805 hospitalizations per 100\u00a0000 during 2010\u20132011 and 2011\u20132012, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In central <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina, influenza <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> caused a substantial number of hospitalizations during multiple periods each year. Our findings strongly suggest that young children should be the highest priority group for annual influenza vaccination in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12205","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T02:08:10Z","timestamp":1384135690000},"page":"53-65","source":"Crossref","is-referenced-by-count":85,"title":["The substantial hospitalization burden of influenza in central <scp>C<\/scp>hina: surveillance for severe, acute respiratory infection, and influenza viruses, 2010\u20132012"],"prefix":"10.1111","volume":"8","author":[{"given":"Hongjie","family":"Yu","sequence":"first","affiliation":[{"name":"Divison of Infectious Disease Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigui","family":"Huang","sequence":"additional","affiliation":[{"name":"Jingzhou Center for Disease 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