{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:17:05Z","timestamp":1767827825636,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>) is an important pathogen in lower respiratory tract infections (<jats:styled-content style=\"fixed-case\">LRTI<\/jats:styled-content>) in infants, but there are limited data concerning patients with underlying conditions and children older than 2\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have designed a prospective observational multicenter national study performed in 26 <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>panish hospitals (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2012). Investigational cases were defined as children with underlying chronic diseases and were compared with a group of previously healthy children (proportion 1:2). Clinical data were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1763 children hospitalized due to <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> infection during the inclusion period were analyzed. Of them, 225 cases and 460 healthy children were enrolled in the study. Underlying diseases observed were respiratory (64%), cardiovascular (25%), and neurologic (12%), as well as chromosomal abnormalities (7\u00b75%), immunodeficiencies (6\u00b77%), and inborn errors of metabolism (3\u00b75%). Cases were statistically older than previously healthy children (average age: 16\u00b73 versus 5\u00b75\u00a0months). Cases experienced hypoxemia more frequently (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), but patients with respiratory diseases required oxygen therapy more often (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2\u00b799; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b703\u20138\u00b765). Mechanical ventilation was used more in patients with cardiac diseases (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3\u00b70; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b707\u20138\u00b744) and in those with inborn errors of metabolism (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 12\u00b727; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2\u00b711\u201371\u00b747). This subgroup showed a higher risk of admission to the <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 6\u00b77, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b718\u201338\u00b704). Diagnosis of pneumonia was more frequently found in cases (18\u00b72% versus 9\u00b73%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant percentage of children with <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> infection have underlying diseases and the illness severity is higher than in healthy children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12224","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T06:16:48Z","timestamp":1388643408000},"page":"209-216","source":"Crossref","is-referenced-by-count":24,"title":["Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5\u00a0years of age in Spain: FIVE multicenter study"],"prefix":"10.1111","volume":"8","author":[{"given":"David","family":"Moreno\u2010Perez","sequence":"first","affiliation":[{"name":"Regional Universitario Hospital M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"Severo Ochoa Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Five Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_9_3_1","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"Glezen WP","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_9_4_1","first-page":"15","article-title":"Description of the outcomes of prior authorization of palivizumab for prevention of respiratory syncytial virus infection in a managed care organization","volume":"16","author":"Buckley B","year":"2010","journal-title":"J Manag Care Pharm"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.3.531"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00454-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.04.063"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31805d01e3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.139188"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199910000-00006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0121-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01714.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182568c67"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1669"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1529-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2011.09.021"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822e68e6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir928"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.774278"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2008.11.007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.11.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1654-8"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:53:13Z","timestamp":1696222393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/irv.12224"],"URL":"https:\/\/doi.org\/10.1111\/irv.12224","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,2]]}}}