{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:36:50Z","timestamp":1784889410120,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Background<\/jats:title>\n \n Human adenovirus 55 (\n HA<\/jats:styled-content>\n dV\u201055) has caused recent outbreaks of acute respiratory disease (\n ARD<\/jats:styled-content>\n ) among adults and military trainees. The active surveillance for\n HA<\/jats:styled-content>\n dV infections was sparse in China, and current knowledge on the\n HA<\/jats:styled-content>\n dV\u2010type distributions and its molecular evolution is lacking.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To acquire better understanding on the prevalence and molecular evolution of\n HA<\/jats:styled-content>\n dV\u201055 strains in China, for an informed strategy for disease control and prevention.\n <\/jats:p>\n <\/jats:sec>\n \n Population\/Methods<\/jats:title>\n \n Nasopharyngeal aspirates were collected from hospitalized children with\n ARTI<\/jats:styled-content>\n in Chongqing during 2009\u20132012. The genotype of\n HA<\/jats:styled-content>\n dV isolates were determined by sequencing the partial hexon and fiber genes. Whole genome sequences of\n HA<\/jats:styled-content>\n dV\u201055 were obtained for molecular evolution analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n About 191 (8\u00b755%)\n HA<\/jats:styled-content>\n dV were detected in 2234 children, including 92 (48\u00b72%) with\n HA<\/jats:styled-content>\n dV\u20107, 72 (37\u00b77%) with\n HA<\/jats:styled-content>\n dV\u20103, 6 (3\u00b71%) with\n HA<\/jats:styled-content>\n dV\u201055, 5 (2\u00b76%) with\n HA<\/jats:styled-content>\n dV\u20105, 4 (2\u00b71%) with\n HA<\/jats:styled-content>\n dV\u20101, 1 (0\u00b75%) with\n HA<\/jats:styled-content>\n dV\u20102, and 11(5\u00b78%) with untyped\n HA<\/jats:styled-content>\n dV. Four of these children developed pneumonia, two of whom were diagnosed with severe pneumonia and\/or encephalopathy.\n HA<\/jats:styled-content>\n dV\u201055 isolates clustered with\n HA<\/jats:styled-content>\n dV\u201011 sequences based on the hexon gene and clustered with\n HA<\/jats:styled-content>\n dV\u201014 sequences based on the fiber gene and the whole genome. The overall evolutionary rates of hexon gene, fiber gene, and whole genome of\n HA<\/jats:styled-content>\n dV\u201055 were estimated at 6\u00b72\u00a0\u00d7\u00a010\n \u22125<\/jats:sup>\n \u00a0s\/s\/y, 8\u00b70\u00a0\u00d7\u00a010\n \u22125\u00a0<\/jats:sup>\n s\/s\/y, and 1\u00b77\u00a0\u00d7\u00a010\n \u22125<\/jats:sup>\n \u00a0s\/s\/y, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study suggested\n HA<\/jats:styled-content>\n dV\u201055 as an emerging infectious disease pathogen has conserved genetic structure and is closely related to each other. Further molecular investigation based on\n HA<\/jats:styled-content>\n dV\u201055 of wider origin might facilitate understanding its diversity, dissemination, and transmission in China.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/irv.12232","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T03:36:59Z","timestamp":1390880219000},"page":"302-308","source":"Crossref","is-referenced-by-count":82,"title":["Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009\u20132012"],"prefix":"10.1111","volume":"8","author":[{"given":"Qing\u2010Bin","family":"Lu","sequence":"first","affiliation":[{"name":"School of Public Health Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Gang","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 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