{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:28:42Z","timestamp":1787729322860,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K01AI101010-01"],"award-info":[{"award-number":["1K01AI101010-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM088558"],"award-info":[{"award-number":["U54GM088558"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hospitalization burden associated with influenza and respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>) is uncertain due to ambiguity in the inference methodologies employed for its estimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Utilization of a new method to quantitate the above burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Weekly hospitalization rates for several principal diagnoses from 2003 to 2011 in New York City by age group were regressed linearly against incidence proxies for the major influenza subtypes and <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> adjusting for temporal trends and seasonal baselines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average annual rates of influenza\u2010associated respiratory hospitalizations per 100\u00a0000 were estimated to be 129 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (79, 179)] for age &lt;1, 36\u00b73 (21\u00b76, 51\u00b74) for ages 1\u20134, 10\u00b76 (7\u00b75, 13\u00b77) for ages 5\u201317, 25\u00b76 (21\u00b73, 29\u00b78) for ages 18\u201349, 65\u00b75 (54\u00b70, 76\u00b79) for ages 50\u201364, 125 (105, 147) for ages 65\u201374, and 288 (244, 331) for ages \u226575. Additionally, influenza had a significant contribution to hospitalization rates with a principal diagnosis of septicemia for ages 5\u201317 [0\u00b776 (0\u00b71, 1\u00b74)], 18\u201349 [1\u00b702 (0\u00b73, 1\u00b77)], 50\u201364 [4\u00b70 (1\u00b77, 6\u00b73)], 65\u201374 [8\u00b78 (2\u00b72, 15\u00b76)], and \u226575 [38\u00b77 (25\u00b77, 52\u00b79)]. <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> had a significant contribution to the rates of respiratory hospitalizations for age &lt;1 [1900 (1740, 2060)], ages 1\u20134 [117 (70, 167)], and \u226575 [175 (44, 312)] [including chronic lower respiratory disease, 90 (43, 140)] as well as pneumonia &amp; influenza hospitalizations for ages 18\u201349 [6\u00b72 (1\u00b71, 11\u00b73)] and circulatory hospitalizations for ages \u226575 [199 (13, 375)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The high burden of <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> hospitalizations among young children and seniors age \u226575 suggests the need for additional control measures such as vaccination to mitigate the impact of annual <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> epidemics. Our estimates for influenza\u2010associated hospitalizations provide further evidence of the burden of morbidity associated with influenza, supporting current guidelines regarding influenza vaccination and antiviral treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12325","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T05:55:22Z","timestamp":1431755722000},"page":"225-233","source":"Crossref","is-referenced-by-count":59,"title":["Estimating the hospitalization burden associated with influenza and respiratory syncytial virus in <scp>N<\/scp>ew <scp>Y<\/scp>ork <scp>C<\/scp>ity, 2003\u20132011"],"prefix":"10.1111","volume":"9","author":[{"given":"Edward","family":"Goldstein","sequence":"first","affiliation":[{"name":"Department of Epidemiology Center for Communicable Disease Dynamics Harvard School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon K.","family":"Greene","sequence":"additional","affiliation":[{"name":"Bureau of Communicable Disease New York City Department of Health and Mental Hygiene Queens NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Olson","sequence":"additional","affiliation":[{"name":"Bureau of Epidemiology Services New York City Department of Health and Mental Hygiene Queens NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Hanage","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Communicable Disease Dynamics Harvard School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lipsitch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Communicable Disease Dynamics Harvard School of Public Health Boston MA USA"},{"name":"Department of Immunology and Infectious Disease Harvard School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Prevention and control of seasonal influenza with vaccines. 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