{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:54:08Z","timestamp":1774079648272,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the aetiology of infection presenting clinically as influenza in hospitalised adults and children in South\u2010East Asia. Such data are important for future management of respiratory infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the aetiology of infection presenting clinically as influenza in those hospitalised in South\u2010East Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Respiratory specimens archived from July 2008 to June 2009 from patients hospitalised with suspected influenza from Indonesia, Thailand and Vietnam were tested for respiratory viruses and atypical bacteria by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1222 patients\u2019 samples were tested. Of 1222, 776 patients (63\u00b75%) were under the age of 5. Viruses detected included rhinoviruses in 229 of 1222 patients (18\u00b77%), bocaviruses in 200 (16\u00b74%), respiratory syncytial viruses in 144 (11\u00b78%), parainfluenza viruses in 140 (11\u00b75%; <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>1: 32; <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>2: 12; <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>3: 71; <jats:styled-content style=\"fixed-case\">PIV<\/jats:styled-content>4: 25), adenovirus in 102 (8\u00b74%), influenza viruses in 93 (7\u00b76%; influenza A: 77; influenza B: 16) and coronaviruses in 23 (1\u00b78%; <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>43: 14; E229: 9). Bacterial pathogens were <jats:italic>Mycoplasma pneumoniae<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a033, 2\u00b77%), <jats:italic>Chlamydophila psittaci<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), <jats:italic>C.\u00a0pneumoniae<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), <jats:italic>Bordetella pertussis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and <jats:italic>Legionella pneumophila<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). Overall, in\u2010hospital case fatality rate was 29 of 1222 (2\u00b74%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Respiratory viruses were the most commonly detected pathogens in patients hospitalised with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and <jats:italic>M.\u00a0pneumoniae,<\/jats:italic> the most common atypical bacterium. The low number of detected influenza viruses demonstrates a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12326","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T05:54:38Z","timestamp":1431755678000},"page":"315-322","source":"Crossref","is-referenced-by-count":22,"title":["Viral and atypical bacterial aetiologies of infection in\u00a0hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia"],"prefix":"10.1111","volume":"9","author":[{"given":"Heiman F. 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Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinh","family":"Van Nguyen","sequence":"additional","affiliation":[{"name":"National Hospital of Tropical Diseases Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau Vinh","family":"Van Nguyen","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liem Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"National Hospital of Pediatrics Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinh Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"National Hospital of Pediatrics Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy Bich Thi","family":"Phung","sequence":"additional","affiliation":[{"name":"National Hospital of Pediatrics Hanoi 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