{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:03:53Z","timestamp":1768341833647,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fond de recherche du Qu\u00e9bec (FRQ)","award":["PITS-15810"],"award-info":[{"award-number":["PITS-15810"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A point\u2010of\u2010care rapid test (<jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content>) may help early and targeted use of antiviral drugs for the management of influenza A infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>(i) To determine whether antiviral treatment based on a <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> for influenza A is cost\u2010effective and, (ii) to determine the thresholds of key test parameters (sensitivity, specificity and cost) at which a <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> based\u2010strategy appears to be cost effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An hybrid \u00ab susceptible, infected, recovered (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>) \u00bb compartmental transmission and Markov decision analytic model was used to simulate the cost\u2010effectiveness of antiviral treatment based on a <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> for influenza A in the social perspective. Data input parameters used were retrieved from peer\u2010review published studies and government databases. The outcome considered was the incremental cost per life\u2010year saved for one seasonal influenza season.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the base\u2010case analysis, the antiviral treatment based on <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> saves 2 lives\/100\u00a0000 person\u2010years and costs $7600 less than the empirical antiviral treatment based on clinical judgment alone, which demonstrates that the <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content>\u2010based strategy is dominant. In one and two way\u2010sensitivity analyses, results were sensitive to the <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> accuracy and cost, to the vaccination coverage as well as to the prevalence of influenza A. In probabilistic sensitivity analyses, the <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> strategy is cost\u2010effective in 66% of cases, for a commonly accepted threshold of $50\u00a0000 per life\u2010year saved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The influenza antiviral treatment based on <jats:styled-content style=\"fixed-case\">POCRT<\/jats:styled-content> could be cost\u2010effective in specific conditions of performance, price and disease prevalence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12359","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T14:11:13Z","timestamp":1447769473000},"page":"113-121","source":"Crossref","is-referenced-by-count":13,"title":["Cost\u2010effectiveness analysis of antiviral treatment in the management of seasonal influenza A: point\u2010of\u2010care rapid test versus clinical judgment"],"prefix":"10.1111","volume":"10","author":[{"given":"L\u00e9on","family":"Nshimyumukiza","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Douville","sequence":"additional","affiliation":[{"name":"Facult\u00e9 des sciences et g\u00e9nie D\u00e9partement de g\u00e9nie \u00e9lectrique Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Fournier","sequence":"additional","affiliation":[{"name":"Facult\u00e9 des sciences et g\u00e9nie D\u00e9partement de g\u00e9nie \u00e9lectrique Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Duplantie","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine D\u00e9partement de m\u00e9decine sociale et pr\u00e9ventive Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana K.","family":"Daher","sequence":"additional","affiliation":[{"name":"Centre de recherche en infectiologie (CRI) CHU de Qu\u00e9bec (CHUQ) Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Charlebois","sequence":"additional","affiliation":[{"name":"Centre de recherche en infectiologie (CRI) CHU de Qu\u00e9bec (CHUQ) Qu\u00e9bec QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Longtin","sequence":"additional","affiliation":[{"name":"Centre de recherche en infectiologie (CRI) CHU de Qu\u00e9bec (CHUQ) Qu\u00e9bec QC Canada"},{"name":"Facult\u00e9 de m\u00e9decine D\u00e9partement de microbiologie\u2010infectiologie et d'immunologie Universit\u00e9 Laval Qu\u00e9bec QC 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