{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:47:15Z","timestamp":1791398835893,"version":"4.3.3"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Network of Pasteur Institutes","award":["PTR 351"],"award-info":[{"award-number":["PTR 351"]}]},{"name":"Institut de Microbiologie et de Maladies Infectieuses (IMMI)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory illness (<jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content>) is recognized as an important cause of morbidity, mortality, and hospitalization among children in developing countries. Little is known, however, in tropical countries like Cameroon about the cause and seasonality of respiratory infections, especially in hospitalized settings.<\/jats:p><jats:p>Objectives: Our study investigates the viral etiology and seasonality of <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> in hospitalized children in Yaounde, Cameroon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective clinic surveillance was conducted to identify hospitalized children aged \u226415\u00a0years presenting with respiratory symptoms \u22645\u2010day duration. Demographic and clinical data, and respiratory specimens were collected. Nasopharyngeal samples were tested for 17 respiratory viruses using a multiplex polymerase chain reaction. The viral distribution and demographic data were statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From September 2011 through September 2013, 347 children aged \u226415\u00a0years were enrolled. At least one virus was identified in each of 65\u00b74% children, of which 29\u00b75% were coinfections; 27\u00b73% were positive for human adenovirus (<jats:styled-content style=\"fixed-case\">hAdV<\/jats:styled-content>), 13\u00b72% for human respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">hRSV<\/jats:styled-content>), 11\u00b75% for rhinovirus\/enterovirus (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>), 10\u00b76% for human bocavirus (<jats:styled-content style=\"fixed-case\">hBoV<\/jats:styled-content>), 9\u00b78% for influenza virus (Inf), 6\u00b76% for human parainfluenza virus (<jats:styled-content style=\"fixed-case\">hPIV<\/jats:styled-content>), 5\u00b77% for human coronavirus (<jats:styled-content style=\"fixed-case\">hCoV<\/jats:styled-content>), and 2\u00b73% for human metapneumovirus (<jats:styled-content style=\"fixed-case\">hMPV<\/jats:styled-content>). While <jats:styled-content style=\"fixed-case\">hRSV<\/jats:styled-content> showed seasonal patterns, <jats:styled-content style=\"fixed-case\">hAdV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> were detected throughout the year and no evident temporal patterns were observed for the remaining viruses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Respiratory viruses were associated with a high burden of hospitalizations among children in Cameroon. Nevertheless, additional studies evaluating asymptomatic Cameroonian children will be important in understanding the relationship between viral carriage and disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12391","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T09:27:47Z","timestamp":1458898067000},"page":"386-393","source":"Crossref","is-referenced-by-count":74,"title":["Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon, 2011\u20132013"],"prefix":"10.1111","volume":"10","author":[{"given":"Sebastien","family":"Kenmoe","sequence":"first","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"},{"name":"D\u00e9partement de Biochimie Universit\u00e9 de Yaound\u00e9 1 Yaounde Cameroun"},{"name":"Virology Service P\u00f4le de Biologie CHU de Caen Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Tchendjou","sequence":"additional","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Astrid","family":"Vernet","sequence":"additional","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzie","family":"Moyo\u2010Tetang","sequence":"additional","affiliation":[{"name":"Essos Hospital Center Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Mossus","sequence":"additional","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamadou","family":"Njankouo\u2010Ripa","sequence":"additional","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeladine","family":"Kenne","sequence":"additional","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Penlap Beng","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie Universit\u00e9 de Yaound\u00e9 1 Yaounde Cameroun"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Vabret","sequence":"additional","affiliation":[{"name":"Virology Service P\u00f4le de Biologie CHU de Caen Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Njouom","sequence":"additional","affiliation":[{"name":"Centre Pasteur of Cameroon International Network of Pasteur Institutes Yaounde Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61901-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21271"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2013.54.122"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2011.01.025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-012-0258-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.03.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504666102"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21891"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000108187.63151.ea"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-56"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis541"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis573"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1508.081422"},{"key":"e_1_2_6_16_1","unstructured":"WHO.CDC protocol of realtime RTPCR for swine flu influenza A (H1N1). 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