{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:43:05Z","timestamp":1776105785910,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Y1\u2010AI\u20105072"],"award-info":[{"award-number":["Y1\u2010AI\u20105072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adenovirus is a recognized cause of influenza\u2010like illness (<jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content>). The proportion of <jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content> attributable to adenovirus is not known. Moreover, knowledge gaps remain with respect to the epidemiologic, virologic, and clinical characteristics of adenovirus\u2010associated <jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content> among otherwise healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational, longitudinal study of &lt;65\u2010year\u2010old patients with febrile <jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content> at five medical centers was conducted from 2009 to 2014. Nasopharyngeal specimens obtained at enrollment were first tested by single\u2010reaction <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for adenovirus, then further evaluated by a multiplex <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assay for other respiratory viral pathogens. Symptoms over a 28\u2010day period were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 1536 individuals, among whom 43 (2\u00b78%) were positive for adenovirus. The median age of cases was 3\u00b74 years (range: 4 months to 41 years). Three were hospitalized. Species and serotype information was available for 33 (76\u00b77%) cases. Species C (<jats:italic>n<\/jats:italic> = 21) was the most common, followed by B3 (<jats:italic>n<\/jats:italic> = 9) and one each of E4a, D46, and A. Species C infections were more frequent in children (<jats:italic>P<\/jats:italic> &lt; 0\u00b701). Half of the cases were positive for at least one other respiratory viral pathogen. Symptoms were generally mild and most commonly included cough (90%), fatigue (79%), rhinorrhea (74%), loss of appetite (71%), and sore throat (64%). Children with non\u2010C adenovirus infection were more likely to report sore throat (<jats:italic>P<\/jats:italic> = 0\u00b705) and hoarseness (<jats:italic>P<\/jats:italic> = 0\u00b706) than those with species C infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adenovirus is frequently detected with other respiratory viruses. Persons with non\u2010C adenovirus infections reported more severe symptoms, suggesting there may be species\u2010specific differences in virulence and\/or host response to infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12392","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T06:42:43Z","timestamp":1460356963000},"page":"414-420","source":"Crossref","is-referenced-by-count":17,"title":["Type\u2010specific clinical characteristics of adenovirus\u2010associated influenza\u2010like illness at five <scp>US<\/scp> military medical centers, 2009\u20132014"],"prefix":"10.1111","volume":"10","author":[{"given":"Michael A.","family":"Koren","sequence":"first","affiliation":[{"name":"Walter Reed National Military Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Naval Medical Center San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary P.","family":"Fairchok","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville MD USA"},{"name":"Madigan Army Medical Center Fort Lewis WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahaniyat","family":"Lalani","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville MD USA"},{"name":"Naval Medical Center Portsmouth VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Danaher","sequence":"additional","affiliation":[{"name":"San Antonio Military Health System San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M.","family":"Schofield","sequence":"additional","affiliation":[{"name":"Madigan Army Medical Center Fort Lewis WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rajnik","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin A.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville MD USA"},{"name":"Naval Health Research Center San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Mor","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelande","family":"Ridor\u00e9","sequence":"additional","affiliation":[{"name":"Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy H.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene V.","family":"Millar","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences Bethesda MD USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21701"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-84-20714"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-010-0084-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1803.111238"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/598520"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu507"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv120"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268899004550"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113563"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318256605e"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.01.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/522970"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/522188"},{"key":"e_1_2_9_15_1","first-page":"1181","article-title":"Acute respiratory disease associated with adenovirus serotype 14\u2013four states, 2006\u20102007","volume":"56","author":"Centers for Disease Control and Prevention","year":"2007","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200010000-00011"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.5.814"},{"key":"e_1_2_9_18_1","first-page":"774","article-title":"Adenovirus type 3 infection with systemic manifestation in apparently normal children","volume":"22","author":"Levy Y","year":"1986","journal-title":"Isr J Med Sci"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112394"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.6.920"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02392-08"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm375"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-2-199607150-00001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085094"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922810392775"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24492"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405870"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00200-11"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.023"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130378"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12392","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:28:44Z","timestamp":1695720524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,13]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/irv.12392"],"URL":"https:\/\/doi.org\/10.1111\/irv.12392","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,13]]}}}