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Following treatment with oseltamivir, neuraminidase (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir\u2010resistant strain, combined with a partial immune reconstitution, was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient.<\/jats:p>","DOI":"10.1111\/irv.12415","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T15:46:43Z","timestamp":1469116003000},"page":"532-535","source":"Crossref","is-referenced-by-count":13,"title":["Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014\u20132015 influenza season in Alberta, Canada"],"prefix":"10.1111","volume":"10","author":[{"given":"Ahsan","family":"Chaudhry","sequence":"first","affiliation":[{"name":"Departments of Oncology and Medicine University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Bastien","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory  Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory  Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Scott","sequence":"additional","affiliation":[{"name":"Surveillance and Assessment, Accountability and Performance  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanti","family":"Pabbaraju","sequence":"additional","affiliation":[{"name":"ProvLab Alberta (Calgary)  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Stewart","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Medicine University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sallene","family":"Wong","sequence":"additional","affiliation":[{"name":"ProvLab Alberta (Calgary)  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Drews","sequence":"additional","affiliation":[{"name":"ProvLab Alberta (Edmonton)  Edmonton AB Canada"},{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization. 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