{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:48:24Z","timestamp":1791355704111,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bayer Vital GmbH, Leverkusen, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Aspirin (acetylsalicylic acid) has been used for more than 115\u00a0years in medicine. Research exists to show that aspirin has antiviral effects in vitro<jats:italic>,<\/jats:italic> for example, by blocking influenza virus propagation via <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB inhibition when used at high concentrations and short\u2010term incubation steps. The aim of this study was to confirm the antiviral activity of aspirin against influenza virus and further elucidate the activity of aspirin against other respiratory viruses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tests to detect antiviral activity were performed using plaque\u2010reduction assays. Aspirin was administered to the virus\u2010infected cell cultures one hour after infection. Prior to these assays, the non\u2010cytotoxic concentrations of aspirin on cells used for propagation of the respective viruses were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aspirin was found to be highly effective against influenza A H1N1 virus. The antiviral activity against further respiratory <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> viruses was less distinct. Respiratory syncytial virus was minimally inhibited. However, the activity of aspirin against rhinoviruses was more pronounced. Aspirin demonstrated antiviral activity against all human rhinoviruses (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>), but the effect on members of the \u201cmajor group\u201d viruses, namely <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>14 and <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>39, was greater than on those of the \u201cminor group,\u201d <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>1A and <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data demonstrate a specific antiviral activity of aspirin against influenza A virus and <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>. The mode of action against rhinoviruses is still unknown and requires further investigation, as does the possibility of aspirin being effective in vivo to treat the common cold.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12421","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T07:08:48Z","timestamp":1471676928000},"page":"85-92","source":"Crossref","is-referenced-by-count":69,"title":["Antiviral activity of aspirin against <scp>RNA<\/scp> viruses of the respiratory tract\u2014an in vitro study"],"prefix":"10.1111","volume":"11","author":[{"given":"Bernadette","family":"Glatthaar\u2010Saalm\u00fcller","sequence":"first","affiliation":[{"name":"Labor Dr. Glatthaar  Ochsenhausen Germany"},{"name":"Department of Pathobiology Institute of Immunology University of Veterinary Medicine Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin H.","family":"Mair","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Institute of Immunology University of Veterinary Medicine Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Saalm\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Institute of Immunology University of Veterinary Medicine Vienna  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2012.01.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.06.002"},{"key":"e_1_2_7_4_1","volume-title":"Aspirin. 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