{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:33:26Z","timestamp":1788287606900,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Background<\/jats:title>Respiratory syncytial virus (RSV<\/jats:styled-content>) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To compare the hospitalization rates due to RSV<\/jats:styled-content> infection and severity of disease between infants with and without Down syndrome (DS<\/jats:styled-content>) born at term and without other associated risk factors for severe RSV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>Patients\/Methods<\/jats:title>In a prospective multicentre epidemiological study, 93 infants were included in the DS<\/jats:styled-content> cohort and 68 matched by sex and data of birth (\u00b11\u00a0week) and were followed up to 1\u00a0year of age and during a complete RSV<\/jats:styled-content> season.<\/jats:p><\/jats:sec>Results<\/jats:title>The hospitalization rate for all acute respiratory infection was significantly higher in the DS<\/jats:styled-content> cohort than in the non\u2010DS<\/jats:styled-content> cohort (44.1% vs 7.7%, P<\/jats:italic><.0001). Hospitalizations due to RSV<\/jats:styled-content> were significantly more frequent in the DH<\/jats:styled-content> cohort than in the non\u2010DS<\/jats:styled-content> cohort (9.7% vs 1.5%, P<\/jats:italic>=.03). RSV<\/jats:styled-content> prophylaxis was recorded in 33 (35.5%) infants with DS<\/jats:styled-content>. The rate of hospitalization according to presence or absence of RSV<\/jats:styled-content> immunoprophylaxis was 3.0% vs 15%, respectively.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Infants with DS<\/jats:styled-content> showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV<\/jats:styled-content> infection compared to non\u2010DS<\/jats:styled-content> infants. Including DS<\/jats:styled-content> infants in recommendations for immunoprophylaxis of RSV<\/jats:styled-content> disease should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12431","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:31:34Z","timestamp":1473453094000},"page":"157-164","source":"Crossref","is-referenced-by-count":34,"title":["Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study"],"prefix":"10.1111","volume":"11","author":[{"given":"Manuel","family":"S\u00e1nchez\u2010Luna","sequence":"first","affiliation":[{"name":"Neonatology Division Hospital Materno Infantil Hospital General Universitario Gregorio Mara\u00f1\u00f3n Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constancio","family":"Medrano","sequence":"additional","affiliation":[{"name":"Cardiology Division Hospital Materno Infantil Hospital General Universitario Gregorio Mara\u00f1\u00f3n Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Lirio","sequence":"additional","affiliation":[{"name":"Social Pediatric Division Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RISK\u201021 Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis211"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1775"},{"key":"e_1_2_8_7_1","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"Glezen WP","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198208123070702"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000136869.21397.6b"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-014-0513-x"},{"key":"e_1_2_8_11_1","first-page":"23","article-title":"The relationship of congenital heart disease and respiratory infection mortality in patients with Down's syndrome","volume":"29","author":"Chaney RH","year":"1985","journal-title":"J Ment Defic Res"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-103"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2012.01413.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0788"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.11.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1695-4033(07)70650-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2008.11.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1654-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/571609"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.11.058"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12431","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:43:06Z","timestamp":1696210986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,30]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/irv.12431"],"URL":"https:\/\/doi.org\/10.1111\/irv.12431","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,30]]}}}