{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:01:49Z","timestamp":1790125309269,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Background<\/jats:title>Respiratory syncytial virus (RSV<\/jats:styled-content>) is a leading cause of hospital admission in young children. With several RSV<\/jats:styled-content> vaccines candidates undergoing clinical trials, recent estimates of RSV<\/jats:styled-content> burden are required to provide a baseline for vaccine impact studies.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To estimate the number of RSV<\/jats:styled-content>\u2010associated hospital admissions in children aged <5\u00a0years in England over a 5\u2010year period from 2007 using ecological time series modelling of national hospital administrative data.<\/jats:p><\/jats:sec>Patients\/Methods<\/jats:title>Multiple linear regression modelling of weekly time series of laboratory surveillance data and Hospital Episode Statistics (HES<\/jats:styled-content>) data was used to estimate the number of hospital admissions due to major respiratory pathogens including RSV<\/jats:styled-content> in children <5\u00a0years of age in England from mid\u20102007 to mid\u20102012, stratified by age group (<6\u00a0months, 6\u201011\u00a0months, 1\u20104\u00a0years) and primary diagnosis: bronchiolitis, pneumonia, unspecified lower respiratory tract infection (LRTI<\/jats:styled-content>), bronchitis and upper respiratory tract infection (URTI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>On average, 33\u00a0561 (95% confidence interval 30\u00a0429\u201038\u00a0489) RSV<\/jats:styled-content>\u2010associated hospital admissions in children <5\u00a0years of age occurred annually from 2007 to 2012. Average annual admission rates were 35.1 (95% CI: 32.9\u201038.9) per 1000 children aged <1\u00a0year and 5.31 (95% CI: 4.5\u20106.6) per 1000 children aged 1\u20104\u00a0years. About 84% (95% CI: 81\u201091%) of RSV<\/jats:styled-content>\u2010associated admissions were for LRTI<\/jats:styled-content>. The diagnosis\u2010specific burden of RSV<\/jats:styled-content>\u2010associated admissions differed significantly by age group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>RSV<\/jats:styled-content> remains a significant cause of hospital admissions in young children in England. Individual\u2010level analysis of RSV<\/jats:styled-content>\u2010associated admissions is required to fully describe the burden by age and risk group and identify optimal prevention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12443","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T06:57:04Z","timestamp":1483685824000},"page":"122-129","source":"Crossref","is-referenced-by-count":114,"title":["Estimating the burden of respiratory syncytial virus (RSV<\/scp>) on respiratory hospital admissions in children less than five years of age in England, 2007\u20102012"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8949-1568","authenticated-orcid":false,"given":"Rachel Melanie","family":"Reeves","sequence":"first","affiliation":[{"name":"Farr Institute of Health Informatics Research London UK"},{"name":"Institute of Child Health University College London London UK"},{"name":"Respiratory Diseases Department Public Health England Colindale London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Hardelid","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research London UK"},{"name":"Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research London UK"},{"name":"Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Warburton","sequence":"additional","affiliation":[{"name":"Statistics and Modelling Economics Department Public Health England Colindale London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ellis","sequence":"additional","affiliation":[{"name":"Virus Reference Department Public Health England Colindale London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Pebody","sequence":"additional","affiliation":[{"name":"Respiratory Diseases Department Public Health England Colindale London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_6_4_1","unstructured":"PATH.RSV Vaccine Snapshot \u2010 PATH Vaccine Resource Library [Internet].2016.http:\/\/www.path.org\/vaccineresources\/details.php?i=1562. 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