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Opponents of gain\u2010of\u2010function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain\u2010of\u2010function research and argue that the anticipated benefits have yet to materialize while the significant risks remain.<\/jats:p>","DOI":"10.1111\/irv.12458","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T07:00:13Z","timestamp":1494745213000},"page":"306-310","source":"Crossref","is-referenced-by-count":6,"title":["Does influenza pandemic preparedness and mitigation require gain\u2010of\u2010function research?"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-9905","authenticated-orcid":false,"given":"Dillon C.","family":"Adam","sequence":"first","affiliation":[{"name":"School of Public Health and Community Medicine UNSW  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Magee","sequence":"additional","affiliation":[{"name":"Biodesign Center for Environmental Security Biodesign Institute Arizona State University  Tempe AZ USA"},{"name":"Department of Biomedical Informatics College of Health Solutions Arizona State University  Tempe AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau M.","family":"Bui","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine UNSW  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Scotch","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine UNSW  Sydney NSW Australia"},{"name":"Biodesign Center for Environmental Security Biodesign Institute Arizona State University  Tempe AZ USA"},{"name":"Department of Biomedical Informatics College of Health Solutions Arizona State University  Tempe AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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