{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:09:09Z","timestamp":1792656549382,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n Background<\/jats:title>\n \n Influenza A viruses (\n IAV<\/jats:styled-content>\n ) result in severe public health problems with worldwide each year. Overresponse of immune system to\n IAV<\/jats:styled-content>\n infection leads to complications, and ultimately causing morbidity and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n Curcumin has been reported to have anti\u2010inflammatory ability. However, its molecular mechanism in immune responses remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We detected the pro\u2010inflammatory cytokine secretion and nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cell (\n NF<\/jats:styled-content>\n \u2010\u03baB)\u2010related protein expression in human macrophages or mice infected by\n IAV<\/jats:styled-content>\n with or without curcumin treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found that the\n IAV<\/jats:styled-content>\n infection caused a dramatic enhancement of pro\u2010inflammatory cytokine productions of human macrophages and mice immune cells. However, curcumin treatment after\n IAV<\/jats:styled-content>\n infection downregulated these cytokines production in a dose\u2010dependent manner. Moreover, the\n NF<\/jats:styled-content>\n \u2010\u03baB has been activated in human macrophages after\n IAV<\/jats:styled-content>\n infection, while administration of curcumin inhibited\n NF<\/jats:styled-content>\n \u2010\u03baB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B\u2010cells inhibitor, alpha (I\u03baB\u03b1), and inhibiting the translocation of p65 from cytoplasm to nucleus.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In summary,\n IAV<\/jats:styled-content>\n infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the\n NF<\/jats:styled-content>\n \u2010\u03baB signaling pathway.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/irv.12459","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T10:20:39Z","timestamp":1498299639000},"page":"457-463","source":"Crossref","is-referenced-by-count":95,"title":["Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the\n NF<\/scp>\n \u2010\u03baB signaling pathway"],"prefix":"10.1111","volume":"11","author":[{"given":"Yiming","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Respiration Medicine The Affiliated Wuxi Second People's Hospital of Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-4991","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiration Medicine The Affiliated Wuxi Second People's Hospital of Nanjing Medical University Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-011-0247-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1209.05-0979"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00291-10"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0173-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-2-425"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2448"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3070"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06287"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.23.14933-14944.2005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0143"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2011.10.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.60.1.8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20059183"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01770C"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.03.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00066"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.05.022"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00651.x"},{"key":"e_1_2_7_21_1","first-page":"469","article-title":"Curcumin attenuates the expression of IL\u20101beta, IL\u20106, and TNF\u2010alpha as well as cyclin E in TNF\u2010alpha\u2010treated HaCaT cells; 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