{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:37:33Z","timestamp":1759412253098,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["1\u2010U01\u2010CI000298"],"award-info":[{"award-number":["1\u2010U01\u2010CI000298"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We determined influenza A(H1N1)pdm09 antibody levels before and after the first wave of the pandemic in an urban community in Dhaka, Bangladesh.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified a cohort of households by stratified random sampling. We collected baseline serum specimens during July\u2010August 2009, just prior to the initial wave of the 2009 pandemic in this community and a second specimen during November 2009, after the pandemic peak. Paired sera were tested for antibodies against A(H1N1)pdm09 virus using microneutralization assay and hemagglutinin inhibition (<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>) assay. A fourfold increase in antibody titer by either assay with a titer of \u226540 in the convalescent sera was considered a seroconversion. At baseline, an <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> titer of \u226540 was considered seropositive. We collected information on clinical illness from weekly home visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We tested 779 paired sera from the participants. At baseline, before the pandemic wave, 1% overall and 3% of persons &gt;60\u00a0years old were seropositive. After the first wave of the pandemic, 211 (27%) individuals seroconverted against A(H1N1)pdm09. Children aged 5\u201017\u00a0years had the highest proportion (37%) of seroconversion. Among 264 (34%) persons with information on clinical illness, 191 (72%) had illness &gt;3\u00a0weeks prior to collection of the follow\u2010up sera and 73 (38%) seroconverted. Sixteen (22%) of these 73 seroconverted participants reported no clinical illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After the first pandemic wave in Dhaka, one in four persons were infected by A(H1N1)pdm09 virus and the highest burden of infection was among the school\u2010aged children. Seroprevalence studies supplement traditional surveillance systems to estimate infection burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12462","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T15:08:40Z","timestamp":1499526520000},"page":"394-398","source":"Crossref","is-referenced-by-count":3,"title":["Infection with influenza A(H1N1)pdm09 during the first wave of the 2009 pandemic: Evidence from a longitudinal seroepidemiologic study in Dhaka, Bangladesh"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-113X","authenticated-orcid":false,"given":"Sharifa","family":"Nasreen","sequence":"first","affiliation":[{"name":"icddr,b  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafizur","family":"Rahman","sequence":"additional","affiliation":[{"name":"icddr,b  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Hancock","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Katz","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doli","family":"Goswami","sequence":"additional","affiliation":[{"name":"icddr,b  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Sturm\u2010Ramirez","sequence":"additional","affiliation":[{"name":"icddr,b  Dhaka Bangladesh"},{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal","family":"Holiday","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacie","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Branch","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wang","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vic","family":"Veguilla","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2010Alain","family":"Widdowson","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia M.","family":"Fry","sequence":"additional","affiliation":[{"name":"Influenza Division Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Abdullah","family":"Brooks","sequence":"additional","affiliation":[{"name":"icddr,b  Dhaka Bangladesh"},{"name":"Johns Hopkins University  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Swine influenza A (H1N1) infection in two children \u2014 Southern California, March\u2013April 2009","volume":"58","author":"Centers for Disease Control and Prevention (CDC)","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization (WHO).World now at the start of 2009 influenza pandemic 2009http:\/\/www.who.int\/mediacentre\/news\/statements\/2009\/h1n1_pandemic_phase6_20090611\/en\/. 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