{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:14:29Z","timestamp":1780989269205,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Influenza is a vaccine preventable disease that causes important morbidity and mortality worldwide. Estimating the burden of influenza disease is difficult. However, there are some methods based in surveillance data and laboratory testing that can be used for this purpose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Estimating the burden of serious illness from influenza by means of hospitalization and death records during the period between 2012 and 2014, and using information from Severe Acute Respiratory Illness (<jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content>) surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To estimate the Chilean rate of influenza\u2010associated hospitalizations and deaths, we applied the influenza positivity of respiratory samples tested in six <jats:styled-content style=\"fixed-case\">SARI<\/jats:styled-content> surveillance sentinel hospitals to the hospitalizations and deaths from the records with <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 codes from influenza and pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Annually, 5320 people are hospitalized for influenza and 447 die for this cause. The annual influenza\u2010associated hospitalization rate for the period was 71.5\/100\u00a0000 person\u2010year for &lt;5\u00a0years old, 11.8\/100\u00a0000 person\u2010year for people between 5 and 64\u00a0years old; and 156.0\/100\u00a0000 person\u2010year for \u226565\u00a0years. The annual mortality rate for the period was 0.08\/100\u00a0000 person\u2010year for &lt;5\u00a0years; 0.3\/100\u00a0000 person\u2010year for people between 5 and 64\u00a0years; and 22.8\/100\u00a0000 person\u2010year for \u226565\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study of influenza burden in Chile. Every year an important quantity of hospitalizations and deaths result from influenza infection. In countries in temperate zones, it is important to know the burden of influenza in order to prepare the health care network and to assess preventive intervention currently in practice and the new ones to implementing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12502","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T04:22:39Z","timestamp":1518668559000},"page":"138-145","source":"Crossref","is-referenced-by-count":24,"title":["Estimating the burden of influenza\u2010associated hospitalizations and deaths in Chile during 2012\u20102014"],"prefix":"10.1111","volume":"12","author":[{"given":"Viviana","family":"Sotomayor","sequence":"first","affiliation":[{"name":"Department of Epidemiology Ministry of Health of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.","family":"Fasce","sequence":"additional","affiliation":[{"name":"Sub\u2010Department of Viral Diseases Instituto de Salud P\u00fablica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Ministry of Health of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"De la Fuente","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Ministry of Health of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-2562","authenticated-orcid":false,"given":"Sergio","family":"Loayza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Ministry of Health of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhee","family":"Palekar","sequence":"additional","affiliation":[{"name":"Pan\u2010American Health Organization  Washington D.C. 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