{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:08:27Z","timestamp":1791893307853,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1045668"],"award-info":[{"award-number":["APP1045668"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reliance on hospital discharge diagnosis codes alone will likely underestimate the burden of respiratory viruses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the epidemiology of respiratory viruses more accurately, we used record linkage to examine data relating to all children hospitalized in Western Australia between 2000 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>We extracted hospital, infectious disease notification and laboratory data of a cohort of children born in Western Australia between 1996 and 2012. Laboratory records of respiratory specimens collected within 48\u00a0hours of admission were linked to hospitalization records. We calculated the frequency and rates of virus detection. To identify groups where under\u2010ascertainment for respiratory viruses was greatest, we used logistic regression to determine factors associated with failure to test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>Nine percentage of 484\u00a0992 admissions linked to a laboratory record for respiratory virus testing. While 62% (n\u00a0=\u00a026\u00a0893) of laboratory\u2010confirmed admissions received respiratory infection diagnosis codes, 38% (n\u00a0=\u00a016\u00a0734) had other diagnoses, notably viral infection of unspecified sites. Of those tested, incidence rates were highest for respiratory syncytial virus (247 per 100\u00a0000 child\u2010years) followed by parainfluenza (63 per 100\u00a0000 child\u2010years). Admissions among older children and those without a respiratory diagnosis were associated with failure to test for respiratory viruses. Linked data can significantly enhance diagnostic codes when estimating the true burden of disease. In contrast to current emphasis on influenza, respiratory syncytial virus and parainfluenza were the most common viral pathogens among hospitalized children. By characterizing those failing to be tested, we can begin to quantify the under\u2010ascertainment of respiratory viruses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12508","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T15:32:41Z","timestamp":1507563161000},"page":"502-510","source":"Crossref","is-referenced-by-count":40,"title":["Record linkage study of the pathogen\u2010specific burden of respiratory viruses in children"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-2741","authenticated-orcid":false,"given":"Faye J.","family":"Lim","sequence":"first","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia  West Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Blyth","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia  West Perth WA Australia"},{"name":"School of Paediatrics and Child Health The University of Western Australia  Perth WA Australia"},{"name":"Department of Infectious Diseases Princess Margaret Hospital for Children  Perth WA Australia"},{"name":"PathWest Laboratory Medicine WA Princess Margaret Hospital for Children  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Fathima","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia  West Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"de Klerk","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia  West Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia  West Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61901-1"},{"key":"e_1_2_9_3_1","first-page":"15","article-title":"Acute lower respiratory infections in Indigenous and Non\u2010indigenous children","volume":"18","author":"Moore HC","year":"2011","journal-title":"Australas Epidemiol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.109"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pit036"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.1999.tb01297.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2008.00160.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02229.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.08.003"},{"key":"e_1_2_9_10_1","unstructured":"Australian Bureau of Statistics.Population by age and sex regions of Australia 2015 [Internet]. 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