{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:00:49Z","timestamp":1792155649663,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T00:00:00Z","timestamp":1512172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Data about influenza mortality burden in northern China are limited. This study estimated mortality burden in Beijing associated with seasonal influenza from 2007 to 2013 and the 2009 H1N1 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We estimated influenza\u2010associated excess mortality by fitting a negative binomial model using weekly mortality data as the outcome of interest with the percent of influenza\u2010positive samples by type\/subtype as predictor variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2007 to 2013, an average of 2375 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1002\u20108688) deaths was attributed to influenza per season, accounting for 3% of all deaths. Overall, 81% of the deaths attributed to influenza occurred in adults aged \u226565\u00a0years, and the influenza\u2010associated mortality rate in this age group was higher than the rate among those aged &lt;65\u00a0years (113.6 [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>49.5\u2010397.4] versus 4.4 [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.7\u201018.6] per 100\u00a0000,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The mortality rate associated with the 2009 H1N1 pandemic in 2009\/2010 was comparable to that of seasonal influenza during the seasonal years (19.9 [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>10.4\u201033.1] vs 17.2 [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>7.2\u201067.5] per 100\u00a0000). People aged &lt;65\u00a0years represented a greater proportion of all deaths during the influenza A(H1N1)pdm09 pandemic period than during the seasonal epidemics (27.0% vs 17.7%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Influenza is an important contributor to mortality in Beijing, especially among those aged \u226565\u00a0years. These results support current policies to give priority to older adults for seasonal influenza vaccination and help to define the populations at highest risk for death that could be targeted for pandemic influenza vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12515","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T23:12:40Z","timestamp":1508541160000},"page":"88-97","source":"Crossref","is-referenced-by-count":35,"title":["Mortality burden from seasonal influenza and 2009 H1N1 pandemic influenza in Beijing, China, 2007\u20102013"],"prefix":"10.1111","volume":"12","author":[{"given":"Shuangsheng","family":"Wu","sequence":"first","affiliation":[{"name":"Beijing Center for Disease Prevention and Control Beijing China"},{"name":"Beijing Research Center for Preventive Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaihua","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control Beijing China"},{"name":"Beijing Research Center for Preventive Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Greene","sequence":"additional","affiliation":[{"name":"United States Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control Beijing China"},{"name":"Beijing Research Center for Preventive Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Su","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control Beijing China"},{"name":"Beijing Research Center for Preventive Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Song","sequence":"additional","affiliation":[{"name":"United States Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela D.","family":"Iuliano","sequence":"additional","affiliation":[{"name":"United States Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-2503","authenticated-orcid":false,"given":"Quanyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control Beijing China"},{"name":"Beijing Research Center for Preventive Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,2]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Influenza. 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