{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:21:11Z","timestamp":1790266871585,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81290345"],"award-info":[{"award-number":["81290345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Background<\/jats:title>Lower respiratory tract illness is a major cause of morbidity and mortality in children worldwide, however, information about the epidemiological and clinical characteristics of LRTI<\/jats:styled-content>s caused by HMPV<\/jats:styled-content> and HB<\/jats:styled-content>oV in China is limited.<\/jats:p><\/jats:sec>Objectives<\/jats:title>Human bocavirus (HB<\/jats:styled-content>oV) and human metapneumovirus (HMPV<\/jats:styled-content>) are two important viruses for children with lower respiratory tract infections (LRTI<\/jats:styled-content>). We aimed to assay the correlation between viral load and clinical characteristics of HB<\/jats:styled-content>oV and HMPV<\/jats:styled-content> with LRTI<\/jats:styled-content> in Changsha, China.<\/jats:p><\/jats:sec>Methods<\/jats:title>Nasopharyngeal aspirates (NPA<\/jats:styled-content>s) from children with LRTI<\/jats:styled-content> were collected. Real\u2010time PCR<\/jats:styled-content> was used to screen HB<\/jats:styled-content>oV and HMPV<\/jats:styled-content>. Analyses were performed using SPSS<\/jats:styled-content> 16.0 software.<\/jats:p><\/jats:sec>Results<\/jats:title>Pneumonia was the most frequent diagnosis. There was no significant difference between HB<\/jats:styled-content>oV\u2010 and HMPV<\/jats:styled-content>\u2010positive patients in age (P\u00a0<\/jats:italic>=\u00a0.506) or hospitalization duration (P\u00a0<\/jats:italic>=\u00a0.280); 24.1% and 18.2% were positive for HB<\/jats:styled-content>oV and HMPV<\/jats:styled-content>. HB<\/jats:styled-content>oV infections peaked in summer (32.2%), and HMPV<\/jats:styled-content> infections peaked in winter (28.9%). The HB<\/jats:styled-content>oV\u2010positive patients had a shorter hospitalization duration than the HB<\/jats:styled-content>oV\u2010negative patients (P\u00a0<\/jats:italic>=\u00a0.021), and the HMPV<\/jats:styled-content>\u2010positive patients had a higher prevalence of fever than the HMPV<\/jats:styled-content>\u2010negative patients (P\u00a0<\/jats:italic>=\u00a0.002). The HB<\/jats:styled-content>oV viral load was significantly higher among patients aged <1\u00a0year (P\u00a0<\/jats:italic>=\u00a0.006). The mean HB<\/jats:styled-content>oV and HMPV<\/jats:styled-content> viral loads were not significantly different between patients with single infections and coinfections. Patients infected with HB<\/jats:styled-content>oV only were older than those coinfected with HB<\/jats:styled-content>oV and other respiratory viruses (P\u00a0<\/jats:italic>=\u00a0.005). No significant difference was found in the clinical characteristics of patients infected with HMPV<\/jats:styled-content> only and those coinfected with HMPV<\/jats:styled-content> and other respiratory viruses.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Pneumonia was the most frequent diagnosis caused by HB<\/jats:styled-content>oV and HMPV<\/jats:styled-content>. Neither HB<\/jats:styled-content>oV nor HMPV<\/jats:styled-content> viral load was correlated with disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12535","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T13:45:27Z","timestamp":1514036727000},"page":"279-286","source":"Crossref","is-referenced-by-count":33,"title":["Human bocavirus and human metapneumovirus in hospitalized children with lower respiratory tract illness in Changsha, China"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-3093","authenticated-orcid":false,"given":"Jie\u2010ying","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Laboratory Medical The First People's Hospital of Hunan Chenzhou Chenzhou China"},{"name":"Key Laboratory for Medical Virology Ministry of Health National Institute for Viral Disease Control and Prevention, China Center for Disease Control Beijing China"},{"name":"Department of 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