{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:44:59Z","timestamp":1761597899713,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50AG047366"],"award-info":[{"award-number":["P50AG047366"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Substantial but inconclusive evidence suggests in utero exposure to influenza infection may be linked with Alzheimer\u2032s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined whether individuals exposed in utero to the 1918 influenza pandemic are at increased risk of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In this cohort study, surveillance data were used to identify months when influenza activity was at its peak during the pandemic. Using birth dates, exposed and unexposed individuals were identified based on whether they were in utero during \u22651 of the peak months. The outcome, any type of dementia, was identified in population\u2010based medical registries. Time and age at risk were restricted so exposed and unexposed had equal time at risk; diagnoses for dementia were assessed between ages 62 and 92, with a maximum of 30\u00a0years at risk. Poisson regression was used to estimate sex\u2010adjusted incidence rate ratios (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 106\u00a0479 exposed and 177\u00a0918 unexposed persons. Using the cumulative risk function, there were similar proportions of exposed and unexposed with a dementia diagnosis at 11.9% and 11.7%, respectively. Across all ages, the <jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> for the association between in utero influenza exposure and any dementia was 1.01 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.99\u20101.04); for Alzheimer's disease, it was 0.97 (0.93\u20101.01). When stratified by age and sex, and when dementia type was examined, estimates of association were also null or close to null.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests there is likely not an association between in utero exposure to the 1918 influenza pandemic and dementia among those 62 and older.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12542","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:50:30Z","timestamp":1516636230000},"page":"314-318","source":"Crossref","is-referenced-by-count":5,"title":["In utero exposure to the 1918 pandemic influenza in Denmark and risk of dementia"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-2761","authenticated-orcid":false,"given":"Noelle M.","family":"Cocoros","sequence":"first","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne G.","family":"Ording","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Horv\u00e1th\u2010Puh\u00f3","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor W.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"},{"name":"Departments of Health Research &amp; Policy and Neurology &amp; Neurological Sciences Stanford University  Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"},{"name":"Departments of Health Research &amp; Policy and Neurology &amp; Neurological Sciences Stanford University  Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448054"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw083"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.11.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174409990031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12202"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1257\/000282805774669943"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxs007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170313122937"},{"key":"e_1_2_7_10_1","unstructured":"Anonymous.Medicinalberetning for kongeriget Danmark. (Medical report for the Kingdom of Denmark.) Sundhedsstyrelsen Copenhagen (1915\u20101922 1954\u20101960 and 1966\u20101972)."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir510"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015242"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810395825"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107084"},{"key":"e_1_2_7_16_1","first-page":"140539","article-title":"Alzheimer's disease: a pathogenetic autoimmune disorder caused by herpes simplex in a gene\u2010dependent manner","volume":"2010","author":"Carter CJ","year":"2010","journal-title":"Int J Alzheimers Dis"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:30:55Z","timestamp":1695573055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/irv.12542"],"URL":"https:\/\/doi.org\/10.1111\/irv.12542","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"type":"print","value":"1750-2640"},{"type":"electronic","value":"1750-2659"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}