{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:45:50Z","timestamp":1791686750347,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content>) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) after hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The recovery of pulmonary functions, exercise capacity, and <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in the survivors of <jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content> due to 2009 pandemic influenza A H1N1 pneumonitis (H1N1\u2010<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content>) was evaluated in a tertiary teaching hospital in northern Taiwan between May 2010 and June 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Data of spirometry, total lung capacity (<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>), diffusing capacity of carbon monoxide (<jats:styled-content style=\"fixed-case\">DL<jats:sub>CO<\/jats:sub><\/jats:styled-content>), and 6\u2010minute walk distance (6<jats:styled-content style=\"fixed-case\">MWD<\/jats:styled-content>) in the patients survived from H1N1\u2010<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content> were collected 1, 3, and 6\u00a0months post\u2010hospital discharge. <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL was evaluated with St. George respiratory questionnaire (<jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine survivors of H1N1\u2010<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content> in the study period were included. All these patients received 2\u00a0months\u2019 pulmonary rehabilitation program. Pulmonary functions and exercise capacity included <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>, forced vital capacity (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>), forced expiratory volume in the first second (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>), <jats:styled-content style=\"fixed-case\">DL<jats:sub>CO<\/jats:sub><\/jats:styled-content>, and 6<jats:styled-content style=\"fixed-case\">MWD<\/jats:styled-content> improved from 1 to 3\u00a0months post\u2010hospital discharge. Only <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> had further significant improvement from 3 to 6\u00a0months. <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL represented as the total score of <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content> had no significant improvement in the first 3\u00a0months but improved significantly from 3 to 6\u00a0months post\u2010discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The impaired pulmonary functions and exercise capacity in the survivors of H1N1\u2010<jats:styled-content style=\"fixed-case\">ARDS<\/jats:styled-content> improved soon at 3\u00a0months after hospital discharge. Their quality of life had keeping improved at 6\u00a0months even though there was no further improvement of their pulmonary functions and exercise capacity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12566","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T11:05:52Z","timestamp":1524222352000},"page":"643-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Recovery of pulmonary functions, exercise capacity, and quality of life after pulmonary rehabilitation in survivors of <scp>ARDS<\/scp> due to severe influenza A (H1N1) pneumonitis"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-0470","authenticated-orcid":false,"given":"Meng\u2010Jer","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Chia\u2010Yi Chang\u2010Gung Memorial Hospital Chang\u2010Gung Medical Foundation  Chiayi 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