{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:10:40Z","timestamp":1778947840816,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Study's objective was to identify risk factors associated with bronchiolitis severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of all children &lt;2\u00a0years old diagnosed with bronchiolitis at the University Medical Centre Ljubljana between May 2014 and April 2015, who were treated as outpatients (paediatric emergency department, <jats:styled-content style=\"fixed-case\">PED<\/jats:styled-content> group) or as inpatients in the standard hospital setting (<jats:styled-content style=\"fixed-case\">WARD<\/jats:styled-content> group) or in the paediatric intensive care unit (<jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> group). Detection of respiratory viruses in nasopharyngeal swab was accomplished by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Severity was assessed by Wang Respiratory Score and hospitalization longer than 24\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 761 children. The three most frequently detected viruses were respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>), human rhinovirus (<jats:styled-content style=\"fixed-case\">hRV<\/jats:styled-content>) and human bocavirus (<jats:styled-content style=\"fixed-case\">hBoV<\/jats:styled-content>) (57.5%, 272\/473; 25.6%, 121\/473; 18.4%, 87\/473). Patient groups differed in Wang Respiratory Score for the severity of bronchiolitis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). No differences regarding the causative viruses were found. There was a lower proportion of children with the presence of more than one virus in <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> group compared to other two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017). The three groups significantly differed in age, birthweight, comorbidities, bronchodilator treatment and antibiotic usage. However, multiple regression analysis revealed that younger age and the use of antibiotics were associated with bronchiolitis severity defined as hospitalization for &gt;24\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Respiratory syncytial virus, <jats:styled-content style=\"fixed-case\">hRV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">hBoV<\/jats:styled-content> were the most frequently detected viruses. The majority of patients admitted to the <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> had only one virus detected. Younger age and the use of antibiotics were associated with bronchiolitis severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12587","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T21:00:35Z","timestamp":1530046835000},"page":"765-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Risk factors for bronchiolitis severity: A retrospective review of patients admitted to the university hospital from central region of Slovenia"],"prefix":"10.1111","volume":"12","author":[{"given":"Ajda","family":"Praznik","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ne\u017ea","family":"Vin\u0161ek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-2844","authenticated-orcid":false,"given":"Ana","family":"Prodan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanja","family":"Er\u010dulj","sequence":"additional","affiliation":[{"name":"RhoSigma  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Pokorn","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Chair of Infectious Diseases Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Mrvi\u010d","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darja","family":"Paro","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Children's Hospital University Medical Centre  Ljubljana Slovenia"},{"name":"Chair of Pediatrics Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uro\u0161","family":"Krivec","sequence":"additional","affiliation":[{"name":"Pulmonology Department University Children's Hospital University Medical Centre  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franc","family":"Strle","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Petrovec","sequence":"additional","affiliation":[{"name":"Chair of Microbiology and Immunology Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"},{"name":"Institute of Microbiology and Immunology Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"\u017dnidar\u0161i\u010d Er\u017een","sequence":"additional","affiliation":[{"name":"Pediatric Clinical Department Community Health Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0160tefan","family":"Grosek","sequence":"additional","affiliation":[{"name":"Chair of Pediatrics Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"},{"name":"Department of Pediatric Surgery and Intensive Care University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31815b4935"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000069765.43405.3b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000879"},{"key":"e_1_2_7_5_1","unstructured":"Toma\u017ei\u010dJ StrleF.Infekcijske bolezni. 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