{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:50:08Z","timestamp":1762005008419,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005612","name":"Shionogi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The relative ability of neuraminidase inhibitors (<jats:styled-content style=\"fixed-case\">NAI<\/jats:styled-content>s) to reduce household influenza transmission when given to index patients is not established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare daily secondary infection rates (<jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>) of influenza A (A\/H1pdm and A\/H3) and B in households of index patients treated with oseltamivir, zanamivir, laninamivir, or peramivir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This Japanese, single\u2010center, prospective, observational study (<jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTR<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> UMIN<\/jats:styled-content>000024650) enrolled index patients with confirmed influenza who were treated with an <jats:styled-content style=\"fixed-case\">NAI<\/jats:styled-content> during 6 influenza seasons (2010\u20102016). Secondary infection patients were household members diagnosed with the same influenza subtype 1\u20107\u00a0days after onset in the index patient. Daily <jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> was calculated using a modified Reed\u2010Frost model. The rate of household members with secondary infection and proportion of households with any secondary infection were also calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Index patients with influenza A (n\u00a0=\u00a01146) or B (n\u00a0=\u00a0661) were enrolled (~3400 total index and secondary patients). Daily <jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> for all virus subtypes was highest when oseltamivir was used (eg, unadjusted estimate: type A, 1.47% vs 0.71%\u20101.13%; type B, 1.30% vs 0.59%\u20100.88%). Pairwise comparisons revealed significant differences in daily <jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">NAI<\/jats:styled-content>s for influenza type A, type B, and subtype A\/H3; for example, for type A, <jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content> was significantly higher with oseltamivir than with peramivir or zanamivir. The rate of household members with secondary infection and proportion of households with any secondary infection also varied between <jats:styled-content style=\"fixed-case\">NAI<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neuraminidase inhibitors differed in their ability to reduce household influenza transmission; transmission was highest with oseltamivir. Physicians may consider effects on household transmission when deciding which <jats:styled-content style=\"fixed-case\">NAI<\/jats:styled-content> to prescribe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12590","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T14:06:09Z","timestamp":1531231569000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effect of neuraminidase inhibitors on household transmission in Japanese patients with influenza A and B infection: A prospective, observational study"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2580-1520","authenticated-orcid":false,"given":"Nobuo","family":"Hirotsu","sequence":"first","affiliation":[{"name":"Hirotsu Clinic  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Saisho","sequence":"additional","affiliation":[{"name":"Shionogi &amp; Co., Ltd  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Shionogi &amp; Co., Ltd  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD008965","article-title":"Neuraminidase inhibitors for preventing and treating influenza in adults and children","volume":"4","author":"Jefferson T","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050740"},{"key":"e_1_2_8_4_1","first-page":"CD002744","article-title":"Neuraminidase inhibitors for preventing and treating influenza in children (published trials only)","volume":"4","author":"Wang K","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113633"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40506-016-0085-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2128"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70041-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj362"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031519"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.01.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/650458"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900231"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3201\/eid\/1706.101161","article-title":"Use of antiviral drugs to reduce household transmission of pandemic (H1N1) 2009, United Kingdom","volume":"17","author":"Pebody RG","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2798"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.748"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2018.1421945"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1007-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S105473"},{"key":"e_1_2_8_20_1","unstructured":"National Institute of Infectious Diseases.Antiviral resistance surveillance in Japan.https:\/\/www.niid.go.jp\/niid\/en\/influ-resist-e\/7682-flu-r-e20171110.html. 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