{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:19:12Z","timestamp":1792811952494,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["71260"],"award-info":[{"award-number":["71260"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["127088"],"award-info":[{"award-number":["127088"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010096","name":"Secretar\u00eda de Educaci\u00f3n P\u00fablica","doi-asserted-by":"publisher","award":["P\/PFCE\u20102016\u201024MSU0011E\u201012"],"award-info":[{"award-number":["P\/PFCE\u20102016\u201024MSU0011E\u201012"]}],"id":[{"id":"10.13039\/100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute respiratory infections are a major cause of morbidity in children and are often caused by viruses. However, the relative severity of illness associated with different viruses is unclear. The objective of this study was to evaluate the risk of hospitalization from different viruses in children presenting with an influenza\u2010like illness (<jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from children 5\u00a0years old or younger participating in an <jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content> natural history study from April 2010 to March 2014 was analyzed. The adjusted odds ratio for hospitalization was estimated in children with infections caused by respiratory syncytial virus (<jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>), metapneumovirus, bocavirus, parainfluenza viruses, rhinovirus\/enterovirus, coronavirus, adenovirus, and influenza.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1486 children (408 outpatients and 1078 inpatients) were included in this analysis. At least one virus was detected in 1227 (82.6%) patients. The most frequent viruses detected as single pathogens were <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> (n\u00a0=\u00a0286), rhinovirus\/enterovirus (n\u00a0=\u00a0251), parainfluenza viruses (n\u00a0=\u00a0104), and influenza A or B (n\u00a0=\u00a099). After controlling for potential confounders (age, sex, recruitment site, days from symptom onset to enrollment, and underlying illnesses), children with <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> and metapneumovirus infections showed a greater likelihood of hospitalization than those infected by parainfluenza viruses (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.7 and 1.9, respectively), rhinovirus\/enterovirus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.1 and 2.1, respectively), coronaviruses (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.9 and 3.4, respectively), adenovirus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.6 and 3.2, respectively), and influenza (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.3 and 4.4, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children presenting with <jats:styled-content style=\"fixed-case\">ILI<\/jats:styled-content> caused by <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content> and metapneumovirus were at greatest risk for hospitalization, while children with rhinovirus\/enterovirus, parainfluenza, coronavirus, adenovirus, and influenza were at lower risk of hospitalization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12606","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T15:25:42Z","timestamp":1535037942000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["\u201cDifferential risk of hospitalization among single virus infections causing influenza\u2010like illnesses\u201d"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6505-0066","authenticated-orcid":false,"given":"Ana A.","family":"Ortiz\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto Nacional de Pediatria  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine K.","family":"Nishimura","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4840-6742","authenticated-orcid":false,"given":"Daniel E.","family":"Noyola","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de San Luis Potosi  San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarbelio","family":"Moreno\u2010Espinosa","sequence":"additional","affiliation":[{"name":"Hospital Infantil de M\u00e9xico Dr. Federico G\u00f3mez  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gami\u00f1o","sequence":"additional","affiliation":[{"name":"Hospital Infantil de M\u00e9xico Dr. Federico G\u00f3mez  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Galindo\u2010Fraga","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Vald\u00e9z V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Hospital General Dr. Manuel Gea Gonz\u00e1lez  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Maga\u00f1a Aquino","sequence":"additional","affiliation":[{"name":"Hospital Regional Dr. Ignacio Morones Prieto  San Luis Potos\u00ed M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Ramirez\u2010Venegas","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Respiratorias  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raydel","family":"Vald\u00e9s Salgado","sequence":"additional","affiliation":[{"name":"Westat  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Andrade\u2010Platas","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatria  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Estevez\u2010Jimen\u00e9z","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatria  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo M.","family":"Ruiz\u2010Palacios","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lourdes","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-4941","authenticated-orcid":false,"given":"John","family":"Beigel","sequence":"additional","affiliation":[{"name":"Frederick National Laboratory for Cancer Research Leidos Biomedical Research, Inc.  Frederick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Smolskis","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Hunsberger","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Freimanis\u2010Hence","sequence":"additional","affiliation":[{"name":"Westat  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-7476","authenticated-orcid":false,"given":"Beatriz","family":"Llamosas\u2010Gallardo","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatria  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Mexico Emerging Infectious Diseases Clinical Research Network (La Red)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1239-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80307-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"e_1_2_5_5_1","unstructured":"Pneumonia \u2010 World Health Organization.http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/pneumonia. Accessed September 4 2018."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31593-8"},{"issue":"12","key":"e_1_2_5_7_1","first-page":"895","article-title":"Global estimate of the incidence of clinical pneumonia among children under five years of age","volume":"82","author":"Rudan I","year":"2004","journal-title":"Bull World Health Organ"},{"key":"e_1_2_5_8_1","unstructured":"SUIVE\/DGE\/Secretaria de Salud\/EstadosUnidosMexicanos2016"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001977"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000100005"},{"issue":"7","key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1099\/jmm.0.05007-0","article-title":"Comparative viral frequency in Mexican children under 5\u00a0years of age with and without upper respiratory symptoms","volume":"52","author":"Manjarrez ME","year":"2013","journal-title":"J Med Microbiol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46052-0"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000110269.46528.a5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.06.020"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176298"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-305"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12211"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.01.006"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197303082881005"},{"issue":"3","key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"e0173504","DOI":"10.1371\/journal.pone.0173504","article-title":"Human metapneumovirus infections in hospitalized children and comparison with other respiratory viruses 2005\u20102014 propective study","volume":"12","author":"Garcia\u2010Garcia ML","year":"2014","journal-title":"PLoS ONE"},{"issue":"6","key":"e_1_2_5_22_1","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"Glezen WP","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1401.070251"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.01.034"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.01.038"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3192"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.10.011"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31816be052"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181a854ae"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/652405"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181757b16"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31827fef67"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T21:19:19Z","timestamp":1694812759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/irv.12606"],"URL":"https:\/\/doi.org\/10.1111\/irv.12606","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"assertion":[{"value":"2018-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}