{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:09:48Z","timestamp":1791616188820,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reports of pregnant women infected with avian influenza are rare. Studies showed that A\/H5N1 virus can penetrate the placental barrier and infect the fetus. Of six documented cases, four died and two survivors had a spontaneous abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report a clinical, outcome and epidemiological characteristics of a 36\u2010week pregnant woman infected with A\/H5N1 and her newborn in Soc Trang province of Vietnam in 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Epidemiological and laboratory investigations were conducted. Clinical manifestations, progress, treatment and outcome of the case\u2010patient and her newborn were collected. Human tracheal aspirate, throat swab and serum specimens were tested for influenza A\/H5N1, A\/H3N1, A\/H1N1pdm09 and B by real\u2010time <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and genome sequencing. Poultry throat and rectal swabs were tested by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and virus isolation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Case\u2010patient hospitalized with high fever and cough, and died after onset 6\u00a0days. She continuously slaughtered sick poultry 5\u00a0days before illness onset. Clinical manifestation showed rapid progressive severe pneumonia. Her tracheal aspirate sample was positive influenza A\/H5N1 virus. Her new\u2010born was delivered by caesarean section with low birth weight and early onset pneumonia, however fully recovered after 16 days treatment. Neonate's throat swabs and paired serum samples tested negative for influenza A\/H5N1. Clade 1.1 A\/H5N1 virus was detected in poultry samples, was same clade and highly homogenous with the virus was detected in the mother.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This was the first documented a live birth from a pregnant woman infected with influenza A\/H5N1 virus. Intensive studies are needed to better understand mother\u2010to\u2010child transmission of influenza A\/H5N1 virus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12614","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T13:59:26Z","timestamp":1538834366000},"page":"292-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fatal avian influenza A(H5N1) infection in a 36\u2010week pregnant woman survived by her newborn in S\u00f3c Tr\u0103ng Province, Vietnam, 2012"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-9000","authenticated-orcid":false,"given":"Tuan Van","family":"Le","sequence":"first","affiliation":[{"name":"World Health Organization Vietnam Country Office Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan T.","family":"Phan","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Pasteur Institute Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh H. K.","family":"Ly","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Pasteur Institute Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Pasteur Institute Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieu T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Pasteur Institute Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan T. T.","family":"Ho","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Pasteur Institute Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung X.","family":"Trinh","sequence":"additional","affiliation":[{"name":"General Department of Preventive Medicine Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen N.","family":"Tran Minh","sequence":"additional","affiliation":[{"name":"World Health Organization Vietnam Country Office Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Impact of Avian Influenza Outbreaks in the Poultry Sectors of Five South East Asian Countries (Cambodia, Indonesia, Lao PDR, Thailand, Viet Nam) Outbreak Costs, Responses and Potential Long Term Control","author":"Rushton J","year":"2004"},{"key":"e_1_2_6_3_1","unstructured":"World Organisation for Animal Health (OIE).OIE Situation Report for avian influenza. [OIE website]. August 31 2018.http:\/\/www.oie.int\/en\/animal-health-in-the-world\/update-on-avian-influenza\/. Accessed April 20 2018."},{"key":"e_1_2_6_4_1","unstructured":"World Health Organization (WHO).Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO. [WHO website]. December 13 2018.http:\/\/www.who.int\/influenza\/human_animal_interface\/H5N1_cumulative_table_archives\/en\/. Accessed April 20 2018."},{"key":"e_1_2_6_5_1","unstructured":"Ho Chi Minh City Pasteur Institute 2012.Annual Report on Communicable Diseases prevention and Control."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2008.140780"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1884"},{"key":"e_1_2_6_8_1","unstructured":"World Health Organization (WHO).WHO guidelines for investigation of human cases of avian influenza A(H5N1). [WHO website]. 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