{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:12:19Z","timestamp":1773796339474,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18fm0108001"],"award-info":[{"award-number":["JP18fm0108001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Influenza B is one of the major etiologies for acute respiratory infections (<jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content>) among children worldwide; however, its clinical\u2010epidemiological information is limited. We aimed to investigate the hospitalization incidence and clinical\u2010epidemiological characteristics of influenza B\u2010associated paediatric <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content>s in central Vietnam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected clinical\u2010epidemiological information and nasopharyngeal swabs from <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content> children hospitalized at Khanh Hoa General Hospital, Nha Trang, Vietnam from February 2007 through June 2013. Nasopharyngeal samples were screened for 13 respiratory viruses using Multiplex\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>s. Influenza B\u2010confirmed cases were genotyped by Haemagglutinin gene sequencing. We analyzed the clinical\u2010epidemiological characteristics of influenza B Lineages (Victoria\/Yamagata) and <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> Groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the pre\u2010A\/H1N1pdm09 period, influenza B\u2010associated <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content> hospitalization incidence among children under five was low, ranging between 14.7 and 80.7 per 100\u00a0000 population. The incidence increased to between 51.4 and 330 in the post\u2010A\/H1N1pdm09. Influenza B <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content> cases were slightly older with milder symptoms. Both Victoria and Yamagata lineages were detected before the A\/H1N1pdm09 outbreak; however, Victoria lineage became predominant in 2010\u20102013 (84% Victoria vs 16% Yamagata). Victoria and Yamagata lineages did not differ in demographic and clinical characteristics. In Victoria lineage, Group1 <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content> cases were clinically more severe compared to Group5, presenting a greater proportion of wheeze, tachypnea, and lower respiratory tract infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current results highlight the increased incidence of influenza B\u2010related <jats:styled-content style=\"fixed-case\">ARI<\/jats:styled-content> hospitalization among children in central Vietnam in the post\u2010A\/H1N1pdm09 era. Furthermore, the difference in clinical severity between Victoria lineage Group1 and 5 implies the importance of influenza B genetic variation on clinical presentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12626","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T17:13:30Z","timestamp":1545412410000},"page":"248-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam"],"prefix":"10.1111","volume":"13","author":[{"given":"Keisuke","family":"Yoshihara","sequence":"first","affiliation":[{"name":"Department of Paediatric Infectious Diseases Institute of Tropical Medicine Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Nhat","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious 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