{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:09:27Z","timestamp":1790143767751,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Influenza A virus in swine (<jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content>\u2010S) causes an acute respiratory disease of swine which results in great economic losses. A bivalent H1N1 and H3N2, <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>1\u2010truncated live\u2010attenuated <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content>\u2010S vaccine (<jats:styled-content style=\"fixed-case\">LAIV<\/jats:styled-content>, Ingelvac Provenza<jats:sup>\u2122<\/jats:sup>) has recently become available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Reduction of shedding during an outbreak in the nursery or finisher is an important parameter from an epidemiological control strategy; therefore, a laboratory efficacy study was conducted to evaluate nasal virus shedding when vaccinated pigs were challenged with either heterologous H1N2 or H3N2 strains 12\u00a0weeks post\u2010vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1 and 5\u00a0days of age, pigs born to <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content>\u2010S seronegative dams were intranasally administered 1\u00a0mL of vaccine or saline. At 30 days post\u2010vaccination, pigs were weaned and randomized into two different challenge groups consisting of vaccinated pigs and control pigs commingled within pens for the two challenge groups. At 85\u00a0days post\u2010vaccination, pigs in the first group were challenged with A\/Swine\/North Carolina\/001169\/2006 H1N2 challenge strain, and the second group was challenged with A\/Swine\/Nebraska\/97901\u201010\/2008 H3N2. Nasal swabs were collected daily for five days and tested by virus isolation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>This study showed significant reduction in nasal virus shedding with regard to both frequency and duration. A 1\u00a0mL intranasal dose of Ingelvac Provenza<jats:sup>\u2122<\/jats:sup> given as early as 1 day of age showed protection for at least 12\u00a0weeks later as evidenced by the reduction of shedding live, viable virus after challenge with either a heterologous H1N2 strain or a heterologous H3N2 strain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12630","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T05:10:55Z","timestamp":1551935455000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Influenza A virus shedding reduction observed at 12 weeks post\u2010vaccination when newborn pigs are administered live\u2010attenuated influenza virus vaccine"],"prefix":"10.1111","volume":"13","author":[{"given":"Troy J.","family":"Kaiser","sequence":"first","affiliation":[{"name":"Boehringer Ingelheim Vetmedica Inc  St. Joseph Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex A.","family":"Smiley","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Vetmedica Inc  St. Joseph Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fergen","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Vetmedica Inc  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Eichmeyer","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Vetmedica Inc  Ames Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-4812","authenticated-orcid":false,"given":"Marika","family":"Genzow","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Vetmedica GmbH  Ingelheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.11.026"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2016.12.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1865-1682.2011.01300.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129213"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2016.0138"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12531"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7535-7543.2005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.09.019"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01439-12"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.10.003"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T15:06:23Z","timestamp":1694358383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/irv.12630"],"URL":"https:\/\/doi.org\/10.1111\/irv.12630","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,6]]},"assertion":[{"value":"2018-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}