{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:23:21Z","timestamp":1793013801515,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rotary Club of Sydney Cove"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Background<\/jats:title>Data on burden of severe influenza in children with a range of chronic lung diseases (CLD<\/jats:styled-content>s) remain limited.<\/jats:p><\/jats:sec>Method<\/jats:title>We performed a cohort study to estimate burden of influenza\u2010associated hospitalization in children with CLD<\/jats:styled-content>s using population\u2010based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD<\/jats:styled-content>); (c) cystic fibrosis (CF<\/jats:styled-content>); (d) other congenital\/chronic lung conditions; and (e) children without CLD<\/jats:styled-content>s. Incidence rates and rate ratios for influenza\u2010associated hospitalization were calculated for 2001\u20102011. Average cost\/episode of hospitalization was estimated using public hospital cost weights.<\/jats:p><\/jats:sec>Results<\/jats:title>Our cohort comprised 888\u00a0157 children; 11\u00a0058 (1.2%) had one of the CLD<\/jats:styled-content>s. The adjusted incidence\/1000 child\u2010years of influenza\u2010associated hospitalization in children with CLD<\/jats:styled-content>s was 3.9 (95% CI<\/jats:styled-content>: 2.6\u20105.2) and 0.7 (95% CI<\/jats:styled-content>: 0.5\u20100.9) for children without. The rate ratio was 5.4 in children with CLD<\/jats:styled-content>s compared to children without. The adjusted incidence\/1000 child\u2010years (95% CI<\/jats:styled-content>) in children with severe asthma was 1.1 (0.6\u20101.6), with BPD<\/jats:styled-content> was 6.0 (3.7\u20108.3), with CF<\/jats:styled-content> was 7.4 (2.6\u201012.1), and with other congenital\/chronic lung conditions was 6.9 (4.9\u20108.9). The cost\/episode (95% CI<\/jats:styled-content>) of influenza\u2010associated hospitalization was AUD<\/jats:styled-content> 19\u00a0704 (95% CI<\/jats:styled-content>: 11\u00a0715\u201027\u00a0693) for children with CLD<\/jats:styled-content>s compared to 4557 (95% CI<\/jats:styled-content>: 4129\u20104984) for children without.<\/jats:p><\/jats:sec>Discussion<\/jats:title>This large population\u2010based study suggests a significant healthcare burden associated with influenza in children with a range of CLD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12633","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T08:32:11Z","timestamp":1548923531000},"page":"233-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Impact of influenza on hospitalization rates in children with a range of chronic lung diseases"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-7964","authenticated-orcid":false,"given":"Nusrat","family":"Homaira","sequence":"first","affiliation":[{"name":"Faculty of Medicine Discipline of Pediatrics School of Women's and Children's Health UNSW Sydney Sydney New South Wales Australia"},{"name":"Respiratory Department Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Briggs","sequence":"additional","affiliation":[{"name":"Stats Central, Mark Wainwright Analytical Centre UNSW Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Lee","family":"Oei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Discipline of Pediatrics School of Women's and Children's Health UNSW Sydney Sydney New South Wales Australia"},{"name":"Department of Newborn Care Royal Hospital for Women Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hilder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Discipline of Pediatrics School of Women's and Children's Health UNSW Sydney Sydney New South Wales Australia"},{"name":"Centre for Big Data Research in Health UNSW Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bajuk","sequence":"additional","affiliation":[{"name":"NSW Pregnancy and Newborn Services Network Sydney Children's Hospitals Network Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Snelling","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital Perth Western Australia Australia"},{"name":"Wesfarmers Centre of Vaccines & Infectious Diseases Telethon Kids Institute University of Western Australia Perth Western Australia Australia"},{"name":"Menzies School of Health Research Charles Darwin University Darwin Northern Territory Australia"},{"name":"School of Public Health Curtin University Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina M.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Discipline of Pediatrics School of Women's and Children's Health UNSW Sydney Sydney New South Wales Australia"},{"name":"Centre for Big Data Research in Health UNSW Sydney Sydney New South Wales Australia"},{"name":"National Perinatal Epidemiology and Statistics Unit (NPESU) Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Discipline of Pediatrics School of Women's and Children's Health UNSW Sydney Sydney New South Wales Australia"},{"name":"Respiratory Department Sydney 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