{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:09:51Z","timestamp":1781500191329,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 302 MERS critically ill patients, NIV was used initially in 105 (35%) patients, whereas 197 (65%) patients were only managed with invasive MV. Patients who were managed with NIV initially had lower baseline SOFA score and less extensive infiltrates on chest radiograph compared with patients managed with invasive MV. The vast majority (92.4%) of patients who were managed initially with NIV required intubation and invasive mechanical ventilation, and were more likely to require inhaled nitric oxide compared to those who were managed initially with invasive MV. ICU and hospital length of stay were similar between NIV patients and invasive MV patients. The use of NIV was not independently associated with 90\u2010day mortality (propensity score\u2010adjusted odds ratio 0.61, 95% CI [0.23, 1.60] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with MERS and acute hypoxemic respiratory failure, NIV failure was very high. The use of NIV was not associated with improved outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12635","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T02:47:28Z","timestamp":1552963648000},"page":"382-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-1829","authenticated-orcid":false,"given":"Basem M.","family":"Alraddadi","sequence":"first","affiliation":[{"name":"Department of Medicine King Faisal Specialist Hospital and Research Center Jeddah Saudi Arabia"},{"name":"Department of Medicine University of Jeddah Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Qushmaq","sequence":"additional","affiliation":[{"name":"Department of Medicine King Faisal Specialist Hospital and Research Center Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad M.","family":"Al\u2010Hameed","sequence":"additional","affiliation":[{"name":"Department of Intensive Care College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Mandourah","sequence":"additional","affiliation":[{"name":"Prince Sultan Military Medical City Military Medical Services, Ministry of Defense Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaleb A.","family":"Almekhlafi","sequence":"additional","affiliation":[{"name":"Prince Sultan Military Medical City Military Medical Services, Ministry of Defense Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesna","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, College of Medicine King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awad","family":"Al\u2010Omari","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Dr. Sulaiman Al\u2010Habib Group Hospitals, College of Medicine Alfaisal University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Kharaba","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Ohoud Hospitals King Fahad Hospital Al\u2010Madinah Al\u2010Monawarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Almotairi","sequence":"additional","affiliation":[{"name":"Critical Care Medicine King Fahad Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim","family":"Al Khatib","sequence":"additional","affiliation":[{"name":"Intensive Care Department Al\u2010Noor Specialist Hospital Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Shalhoub","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases, University of Western Ontario London Canada"},{"name":"Department of Medicine Division of Infectious Diseases, King Fahad Armed Forces Hospital Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdulmomen","sequence":"additional","affiliation":[{"name":"King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mady","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care Tanta University Hospitals Tanta Egypt"},{"name":"Intensive Care Department King Saud Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman","family":"Solaiman","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsalam M.","family":"Al\u2010Aithan","sequence":"additional","affiliation":[{"name":"Intensive Care Department King Abdulaziz Hospital Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaa","family":"Al\u2010Raddadi","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine King Abdulaziz University Hospital, Ministry of Health Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ragab","sequence":"additional","affiliation":[{"name":"Intensive Care Department King Fahd Hospital Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan H.","family":"Balkhy","sequence":"additional","affiliation":[{"name":"Infection Prevention and Control Department, King Abdullah International Medical Research Center, College of Medicine King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Al Harthy","sequence":"additional","affiliation":[{"name":"Intensive Care Department King Saud Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musharaf","family":"Sadat","sequence":"additional","affiliation":[{"name":"Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham","family":"Tlayjeh","sequence":"additional","affiliation":[{"name":"Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Merson","sequence":"additional","affiliation":[{"name":"Infectious Diseases Data Observatory, Churchill Hospital Oxford University, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) Headington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick G.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and International Health University of Virginia School of Medicine, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Department of Medicine, Sunnybrook Hospital, Institute of Health Policy Management and Evaluation University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-6241","authenticated-orcid":false,"given":"Yaseen M.","family":"Arabi","sequence":"additional","affiliation":[{"name":"Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Saudi Critical Care Trials Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1408795"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211721"},{"key":"e_1_2_8_4_1","unstructured":"WHO.Disease outbreak news;2017.http:\/\/www.who.int\/csr\/don\/06-june-2017-mers\/en\/. Accessed June 10 2017."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70204-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2486"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408636"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.132"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.09.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000251821.44259.F3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201206-034OC"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4087-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1306OC"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3.845"},{"issue":"17","key":"e_1_2_8_15_1","first-page":"1413","article-title":"Non\u2010invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome","volume":"118","author":"Yam LY","year":"2005","journal-title":"Chin Med J"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-004-0097-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200305-715OC"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1496"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8044"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2517"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002621"},{"issue":"8","key":"e_1_2_8_22_1","first-page":"897","article-title":"Infection prevention and control guidelines for patients with Middle East Respiratory Syndrome Coronavirus (MERS\u2010CoV) infection","volume":"35","author":"Madani TA","year":"2014","journal-title":"Saudi Med J"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331301"},{"key":"e_1_2_8_24_1","first-page":"CD005351","article-title":"Non\u2010invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema","volume":"5","author":"Vital FM","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1114-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2475-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01209"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2016.02.005"},{"issue":"12","key":"e_1_2_8_29_1","first-page":"1653","article-title":"Role of noninvasive ventilation in acute lung injury\/acute respiratory distress syndrome: a proportion meta\u2010analysis","volume":"55","author":"Agarwal R","year":"2010","journal-title":"Respir Care"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503326"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.6338"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2344"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035797"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1934"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/512819"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12635","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:31:48Z","timestamp":1693963908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/irv.12635"],"URL":"https:\/\/doi.org\/10.1111\/irv.12635","archive":["Portico"],"relation":{},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]},"assertion":[{"value":"2018-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}