{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:46:04Z","timestamp":1782737164796,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18fm0108013"],"award-info":[{"award-number":["JP18fm0108013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H02642"],"award-info":[{"award-number":["JP16H02642"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is one of the main viral causes of lower respiratory tract illness (LRTI), especially in young children. RSV vaccines, including maternal and infant vaccines, are under development; however, more epidemiological studies are needed to develop effective vaccination strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate detailed age\u2010specific incidence rates and severity of RSV\u2010associated LRTI (RSV\u2010LRTI) using data from a community\u2010based prospective cohort study in the Philippines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Cohort children who visited health facilities due to acute respiratory symptoms were identified, and nasopharyngeal swabs were collected to detect RSV. The severity of RSV\u2010LRTI was assessed using the severity definition proposed by the World Health Organization. Risk factors for developing RSV\u2010LRTI and contribution of SpO<jats:sub>2<\/jats:sub> measurement were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 395 RSV episodes which occurred in children aged 2\u201059\u00a0months were categorised as 183 RSV\u2010LRTI, 72 as severe RSV\u2010LRTI and 29 as very severe RSV\u2010LRTI. Children aged 3\u20105\u00a0months had the highest incidence rate of RSV\u2010LRTI, at 207.4 per 1000 child\u2010years (95% CI: 149.0\u2010279.5). Younger age group, place of living and low educational level of caregivers were associated with developing RSV\u2010LRTI. Clinical manifestations had low levels of agreement with hypoxaemia as measured by pulse oximeter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The highest burden of RSV was observed in young infants aged 3\u20105\u00a0months, whereas the burden was also high in those aged 12\u201020\u00a0months. Future vaccination strategies should consider the protection of older children, especially those aged one year, as well as young infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12639","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T05:17:13Z","timestamp":1553059033000},"page":"339-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Age\u2010specific incidence rates and risk factors for respiratory syncytial virus\u2010associated lower respiratory tract illness in cohort children under 5 years old in the Philippines"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-7943","authenticated-orcid":false,"given":"Fumihiko","family":"Ueno","sequence":"first","affiliation":[{"name":"Department of Virology Tohoku University Graduate School of Medicine Sendai 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