{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:14:43Z","timestamp":1780323283693,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously estimated Singapore's influenza\u2010associated hospitalisation rate for pneumonia and influenza (P&amp;I) in 2010\u20102012 to be 29.6 per 100\u00a0000 person\u2010years, which corresponds to 11.2% of all P&amp;I hospitalisations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to update Singapore's estimates of the influenza\u2010associated pneumonia and influenza (P&amp;I) hospitalisation burden using the latest data from 2010 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We estimated the number of P&amp;I hospitalisations associated with influenza using generalised additive models. We specified the weekly number of admissions for P&amp;I and the weekly influenza positivity in the models, along with potential confounders such as weekly respiratory syncytial virus (RSV) positivity and meteorological data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2010\u20102017, 16.3% of all P&amp;I hospitalisations in Singapore were estimated to be attributed to influenza, corresponding to an excess influenza\u2010associated P&amp;I hospitalisation rate of 50.1 per 100\u00a0000 person\u2010years. Higher excess rates were estimated for children aged 0\u20104\u00a0years (186.8 per 100\u00a0000 person\u2010years) and elderly aged\u00a0\u2265\u00a065\u00a0years (338.0 per 100\u00a0000 person\u2010years). Higher influenza\u2010associated hospitalisation rates were estimated for 2016 and 2017 (67.9 and 75.1 per 100\u00a0000 persons, respectively) years when the influenza A(H3N2) subtype was dominant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Influenza burden in Singapore has increased since 2010. Influenza vaccination programmes should continue to be prioritised for the young and the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12676","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T12:28:32Z","timestamp":1566390512000},"page":"574-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Estimates of influenza\u2010associated hospitalisations in tropical Singapore, 2010\u20102017: Higher burden estimated in more recent years"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-9374","authenticated-orcid":false,"given":"Yixiang","family":"Ng","sequence":"first","affiliation":[{"name":"Epidemiology and Disease Control Division Ministry of Health Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Ai Vee","family":"Chua","sequence":"additional","affiliation":[{"name":"Epidemiology and Disease Control Division Ministry of Health Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-5045","authenticated-orcid":false,"given":"Stefan","family":"Ma","sequence":"additional","affiliation":[{"name":"Epidemiology and Disease Control Division Ministry of Health Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon","family":"Jian Ming Lee","sequence":"additional","affiliation":[{"name":"Communicable Diseases Division Ministry of Health Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"69\u201089","article-title":"Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the global burden of disease study 2017","volume":"7","author":"GBD 2017 Influenza Collaborators","year":"2017","journal-title":"Lancet Respir Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70034-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33293-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12434"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12500"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Estimating the burden of influenza\u2010associated hospitalizations and deaths in Chile during 2012\u20132014","author":"Sotomayor V","year":"2018","journal-title":"Influenza Other Respi Viruses"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12496"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Influenza\u2010associated mortality in South Africa, 2009\u20132013: the importance of choices related to influenza infection proxies","author":"Gul D","year":"2017","journal-title":"Influenza Other Respi Viruses"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12501"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.11.013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3128-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.09.017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008096"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1201.050826"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2010.131768"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149468"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01021-x"},{"key":"e_1_2_6_19_1","first-page":"153","article-title":"Delgado\u2010Sanz C, Larrauri A, the Spanish Influenza Surveillance System. 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