{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:01:36Z","timestamp":1792414896827,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T00:00:00Z","timestamp":1570924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In tropical Singapore, influenza occurs all year\u2010round. This study of influenza\u2010confirmed hospitalized pediatric patients compared clinical characteristics and complications by age\u2010group and differences between influenza A and B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of pediatric inpatients from January 2013 to December 2014. Patients were grouped into: &lt;6\u00a0months, 6\u00a0months to &lt;5\u00a0years, 5\u2010 to &lt;10\u2010year and \u226510\u00a0years. Complications were classified into neurologic, pulmonary, and other. We also calculated the incidence of hospitalized influenza cases per 100\u00a0000 age\u2010related population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were a total of 1272 patients with a median age of 37\u00a0months. The highest hospitalization rates were in the &lt;6\u00a0months age\u2010group. Majority (75.2%) had no comorbidity; 25.6% had complications: neurologic 11.9%, pulmonary 9.6%, other 4.1%. Patients with other complications were older, male, and had the highest influenza B rates and the longest length of stay. Influenza A comprised 76.9% of cases and had higher complication rates especially neurologic, compared to influenza B. Influenza B patients were older and were more likely to develop other complications. The 6\u2010month to &lt;5\u2010year\u2010age\u2010group had the highest complication rate (30.6%), especially neurologic. However, \u226510\u00a0years old had the highest other complications, ICU\/ high\u2010dependency admissions and influenza B Victoria rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infants &lt;6\u00a0months had the highest hospitalization rates for influenza. The 6\u2010month to &lt;5\u2010year\u2010age\u2010group had the highest complication rate especially neurologic. Influenza A patients were younger, had higher seizure rates and complications compared to influenza B.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12692","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T04:53:33Z","timestamp":1571028813000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The burden and clinical manifestation of hospitalized influenza among different pediatric age\u2010groups in the tropics"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-3324","authenticated-orcid":false,"given":"Chia\u2010Yin","family":"Chong","sequence":"first","affiliation":[{"name":"Infectious Diseases Department of Paediatrics KK Women\u2019s and Children\u2019s Hospital Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Fu","family":"Yung","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Paediatrics KK Women\u2019s and Children\u2019s Hospital Singapore"},{"name":"Duke\u2010NUS Medical School Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie","family":"Gan","sequence":"additional","affiliation":[{"name":"Singhealth Residency Programme Singapore General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu\u2010Tien","family":"Thio","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Paediatrics KK Women\u2019s and Children\u2019s Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Woon\u2010Hui","family":"Tan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Paediatrics KK Women\u2019s and Children\u2019s Hospital Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Wen\u2010Sim","family":"Tee","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Department of Laboratory Medicine National University Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Lin","sequence":"additional","affiliation":[{"name":"National Public Health Laboratory Ministry of Health Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Tze\u2010Pin","family":"Lin","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Department of Laboratory Medicine National University Hospital Singapore"},{"name":"National Public Health Laboratory Ministry of Health Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh\u2010Cheng","family":"Thoon","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Paediatrics KK Women\u2019s and Children\u2019s Hospital Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"57","article-title":"Influenza surveillance in Singapore 1972\u201386","volume":"66","author":"Doraisingham S","year":"1988","journal-title":"Bull World Health Organ"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24566"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2010.131768"},{"key":"e_1_2_7_5_1","first-page":"232","article-title":"Risk factors for complicated influenza A (H1N1) 2009 disease in children","volume":"42","author":"Chong CY","year":"2013","journal-title":"Annals Acad Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2527"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70252-8"},{"key":"e_1_2_7_8_1","unstructured":"World Health Organization.WHO information for molecular diagnosis of influenza virus \u2013 update. 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