{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:08:45Z","timestamp":1768489725215,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, we evaluated the diagnostic potential and clinical impact of an automated multiplex PCR platform (the FilmArray Respiratory Panel; FA\u2010RP), specially designed for pathogen detection in respiratory tract infections in adults with unexplained pneumonia (UP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 112 UP patients in Shanghai, China, were enrolled prospectively and assessed using the FA\u2010RP from October 2016 to March 2018. We examined the test results and their influence on clinical decisions. Furthermore, as a control group, we retrospectively obtained the clinical data of 70 UP patients between October 2014 and March 2016 (before the FA\u2010RP was available). The two patient groups were compared with respect to factors, including general antimicrobial use and defined daily dose (DDD) numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between October 2016 and March 2018, the positive rate obtained using FA\u2010RP for UP was 76.8%. The primary pathogens in adults with UP were Influenza A\/B (47.3%, 53\/112). Compared with the patients before FA\u2010RP was available, patients who underwent FA\u2010RP testing had higher rates of antiviral drug use and antibiotic de\u2010escalation during clinical treatment. FA\u2010RP significantly decreased the total DDDs of antibiotic or antifungal drugs DDDs by 7\u00a0days after admission (10.6\u00a0\u00b1\u00a02.5 vs 14.1\u00a0\u00b1\u00a08.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FA\u2010RP is a rapid and sensitive nucleic acid amplification test method for UP diagnosis in adults. The application of FA\u2010RP may lead to a more accurately targeted antimicrobial treatment and reduced use of antibiotic\/antifungal drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12701","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T13:29:38Z","timestamp":1575293378000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Rapid detection of respiratory organisms with FilmArray respiratory panel and its impact on clinical decisions in Shanghai, China, 2016\u20102018"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-3894","authenticated-orcid":false,"given":"Yiyi","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Huashan Hospital Fudan University Shanghai China"},{"name":"State Key Laboratory of Genetic Engineering School of Life Science Fudan University Shanghai China"},{"name":"National Clinical Research Center for Aging and Medicine Huashan Hospital Fudan University Shanghai China"},{"name":"Key Laboratory of Medical Molecular Virology (MOE\/MOH) and Institutes of Biomedical Sciences Shanghai Medical College Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-2659.2011.00248.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-1049(03)00064-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70827-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026047"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01523-14"},{"key":"e_1_2_6_7_1","unstructured":"Methodology W.C.C.F. 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