{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:05:20Z","timestamp":1790949920118,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is a major cause of hospital admission for acute lower respiratory tract infection in young children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to identify risk factors for hospitalized RSV disease and its severe outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study analyzing data of a ICD\u201010\u2010code\u2010based hospital surveillance for severe acute respiratory infections (SARI). Using univariable and multivariable logistic regression analysis, we assessed age\u2010group, gender, season, and underlying medical conditions as possible risk factors for RSV and its severe outcomes including ICU admission, application of ventilator support, and death, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 413\u00a0552 patients hospitalized with SARI in the database, 8761 were diagnosed with RSV from week 01\/2009 to 20\/2018 with 97% (8521) aged &lt;5\u00a0years. Among children aged &lt;5\u00a0years, age\u2010groups 0\u20105\u00a0months (OR: 20.29, 95% CI: 18.37\u201022.41) and 6\u00a0months\u20101\u00a0year (OR: 4.59, 95% CI: 4.16\u20105.06), and underlying respiratory and cardiovascular disorders specific to the perinatal period (OR: 1.32, 95% CI: 1.11\u20101.57) were risk factors for being diagnosed with RSV. Age\u2010group 0\u20105\u00a0months (OR: 2.39, 95% CI: 1.45\u20103.94), low birth weight (OR: 6.77, 95% CI: 1.28\u201035.71), preterm newborn (OR: 6.71, 95% CI: 2.19\u201020.61), underlying respiratory and cardiovascular disorders specific to the perinatal period (OR: 4.97, 95% CI: 3.36\u20107.34), congenital malformation of the heart (OR: 3.65, 95% CI: 1.90\u20107.02), congenital malformation of the great vessels (OR: 3.50, 95% CI: 1.10\u201011.18), congenital defect originating in perinatal period (OR: 4.07, 95% CI: 1.71\u20109.70), cardiovascular disease (OR: 5.19, 95% CI: 2.77\u20109.72), neurological disorders (OR: 6.48, 95% CI: 3.76\u201011.18), blood disease (OR: 3.67, 95% CI: 1.98\u20106.79), and liver disease (OR: 14.99, 95% CI: 1.49\u2010150.82) contributed to ICU admission in RSV cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using ICD\u201010\u2010based surveillance data allows to identify risk factors for hospitalized RSV disease and its severe outcomes, and quantify the risk in different age\u2010groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/irv.12729","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T05:34:12Z","timestamp":1581917652000},"page":"658-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Risk factors for hospitalized respiratory syncytial virus disease and its severe outcomes"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-4880","authenticated-orcid":false,"given":"Wei","family":"Cai","sequence":"first","affiliation":[{"name":"Respiratory Infections Unit Department for Infectious Disease Epidemiology Robert Koch Institute Berlin Germany"},{"name":"Medizinische Fakult\u00e4t Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Buda","sequence":"additional","affiliation":[{"name":"Respiratory Infections Unit Department for Infectious Disease Epidemiology Robert Koch Institute Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Schuler","sequence":"additional","affiliation":[{"name":"HELIOS KLINIKEN GmbH Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-7789","authenticated-orcid":false,"given":"Siddhivinayak","family":"Hirve","sequence":"additional","affiliation":[{"name":"Global Influenza Programme World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Global Influenza Programme World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Haas","sequence":"additional","affiliation":[{"name":"Respiratory Infections Unit Department for Infectious Disease Epidemiology Robert Koch Institute Berlin Germany"},{"name":"Medizinische Fakult\u00e4t Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4946.18.05316-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3289-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.05.093"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30292-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.05.020416"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1295"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801105010144"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.110531"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.505126"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4515-1"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Evaluation of using ICD\u201010 code data for respiratory syncytial virus surveillance","volume":"00","author":"Cai W","year":"2019","journal-title":"Influenza Other Respi Viruses"},{"key":"e_1_2_8_16_1","unstructured":"World Health Organization.International Statistical Classification of Diseases and Related Health Problems 10th Revision. 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