{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:39Z","timestamp":1791946119315,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) infection is implicated in subsequent development of asthma\/wheezing (AW) among term and pre\u2010term infants. We describe the cumulative incidence of AW among hospitalized and ambulatory neonates\/infants\/toddlers following RSV infection diagnosis over three independent follow\u2010up periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between January 1, 2007 and March 31, 2016, patients aged 0\u20102\u00a0years old with first clinical diagnosis of RSV infection were identified using the Optum\n                      <jats:sup>\u00ae<\/jats:sup>\n                      integrated electronic health records and claims database. Patients diagnosed with AW\u00a0\u2264\u00a030\u00a0days post\u2010RSV diagnosis were excluded. Three cohorts with 1, 3, and 5\u00a0years of follow\u2010up were stratified by presence or absence of specific RSV high\u2010risk factors, including pre\u2010term birth and pre\u2010defined, pre\u2010existing comorbidities. Descriptive statistics and logistic regression results were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 9811, 4524, and 1788 RSV\u2010infected high\u2010risk factor negative patients were included in 1, 3, and 5\u2010year independent cohorts, respectively. Of these, 6.5%, 6.9%, and 5.8%, respectively had RSV\u2010related hospitalization. By the end of follow\u2010up, 14.9%, 28.2%, and 36.3% had AW events. Overall, 3030, 1378, and 552 RSV\u2010infected high\u2010risk factor positive patients were included in the respective cohorts. Of these, 11.4%, 11.1%, and 11.6%, respectively were hospitalized with initial RSV infection and 18.1%, 32.9%, and 37.9% had subsequent AW events within the follow\u2010up period. Logistic regression confirmed RSV\u2010related hospitalization significantly increased the likelihood of developing AW (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) in high\u2010risk factor positive and negative patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In infants diagnosed with RSV infection, RSV\u2010related hospitalization was associated with a significantly increased likelihood of AW development for at least 5\u00a0years, compared with non\u2010hospitalized patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12770","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T01:46:37Z","timestamp":1592012797000},"page":"730-738","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cumulative incidence of post\u2010infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"Jonathan","family":"Nguyen\u2010Van\u2010Tam","sequence":"first","affiliation":[{"name":"Health Protection and Influenza Research Group University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Wyffels","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica NV Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"Smulders","sequence":"additional","affiliation":[{"name":"SmartAnalyst New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Mazumder","sequence":"additional","affiliation":[{"name":"SmartAnalyst Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Tyagi","sequence":"additional","affiliation":[{"name":"SmartAnalyst Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Gupta","sequence":"additional","affiliation":[{"name":"SmartAnalyst Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gavart","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica NV Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-6410","authenticated-orcid":false,"given":"Roman","family":"Fleischhackl","sequence":"additional","affiliation":[{"name":"Janssen\u2010Cilag Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00056.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405870"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_8_6_1","unstructured":"Centers for Disease Control and Prevention.https:\/\/www.cdc.gov\/rsv\/high\u2010risk\/index.html. 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