{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:52:18Z","timestamp":1792651938890,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe COVID\u201019 patients typically test positive for SARS\u2010CoV\u20102 RNA for extended periods of time, even after recovery from severe disease. Due to the timeframe involved, these patients may have developed humoral immunity to SARS\u2010CoV\u20102 while still testing positive for viral RNA in swabs. Data are lacking on exposure risks in these situations. Here, we studied SARS\u2010CoV\u20102 environmental contamination in an ICU and an isolation ward caring for such COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected air and surface samples in a hospital caring for critical and severe COVID\u201019 cases from common areas and areas proximal to patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 218 ICU samples, an air sample contained SARS\u2010CoV\u20102 RNA. Of the 182 isolation ward samples, nine contained SARS\u2010CoV\u20102 RNA. These were collected from a facemask, the floor, mobile phones, and the air in the patient room and bathroom. Serum antibodies against SARS\u2010CoV\u20102 were detected in these patients at the beginning of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While there is a perception of increased risk in the ICU, our study demonstrates that isolation wards may pose greater risks to healthcare workers and exposure risks remain with clinically improved patients, weeks after their initial diagnoses. As these patients had serum antibodies, further studies may be warranted to study the utility of serum antibodies as a surrogate of viral clearance in allowing people to return to work. We recommend continued vigilance even with patients who appear to have recovered from COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12783","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T08:26:18Z","timestamp":1592987178000},"page":"688-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["SARS\u2010CoV\u20102 environmental contamination associated with persistently infected COVID\u201019 patients"],"prefix":"10.1111","volume":"14","author":[{"given":"Hui","family":"Lei","sequence":"first","affiliation":[{"name":"Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"},{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"},{"name":"Department of Intensive Care The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenting","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiman","family":"Ling","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanpeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Guangzhou Medical University  Guangzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7314-840X","authenticated-orcid":false,"given":"Nancy H. L.","family":"Leung","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public Health The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-7154","authenticated-orcid":false,"given":"Benjamin J.","family":"Cowling","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public Health The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology and Surgery The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-191X","authenticated-orcid":false,"given":"Sook\u2010San","family":"Wong","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"},{"name":"WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public Health The University of Hong Kong  Hong Kong SAR China"},{"name":"Guangzhou Institute of Respiratory Health  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-1744","authenticated-orcid":false,"given":"Mark","family":"Zanin","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory Disease  Guangzhou China"},{"name":"WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public Health The University of Hong Kong  Hong Kong SAR China"},{"name":"Guangzhou Institute of Respiratory Health  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200885"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3227"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15562-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2606.200301"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa149"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2004973"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1729071"},{"issue":"5","key":"e_1_2_8_9_1","first-page":"434","article-title":"Prolonged presence of SARS\u2010CoV\u20102 viral RNA in faecal samples. 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