{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:31:47Z","timestamp":1773808307298,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["215654\/Z\/19\/Z"],"award-info":[{"award-number":["215654\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Point\u2010of\u2010care tests (POCTs) offer considerable potential for improving clinical and public health management of COVID\u201019 by providing timely information to guide decision\u2010making, but data on real\u2010world performance are in short supply. Besides SARS\u2010CoV\u20102\u2010specific tests, there is growing interest in the role of surrogate (non\u2010specific) tests such as FebriDx, a biochemical POCT which can be used to distinguish viral from bacterial infection in patients with influenza\u2010like illnesses. This short report assesses what is currently known about FebriDx performance across settings and populations by comparison with some of the more intensively evaluated SARS\u2010CoV\u20102\u2010specific POCTs. While FebriDx shows some potential in supporting triage for early\u2010stage infection in acute care settings, this is dependent on SARS\u2010CoV\u20102 being the most likely cause for influenza\u2010like illnesses, with reduction in discriminatory power when COVID\u201019 case numbers are low, and when co\u2010circulating viral respiratory infections become more prevalent during the autumn and winter. Too little is currently known about its performance in primary care and the community to support use in these contexts, and further evaluation is needed. Reliable SARS CoV2\u2010specific POCTs\u2014when they become available\u2014are likely to rapidly overtake surrogates as the preferred option given the greater specificity they provide.<\/jats:p>","DOI":"10.1111\/irv.12796","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T02:28:04Z","timestamp":1596767284000},"page":"3-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Horses for courses? Assessing the potential value of a surrogate, point\u2010of\u2010care test for SARS\u2010CoV\u20102 epidemic control"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-7337","authenticated-orcid":false,"given":"Sharif A.","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Global Health and Development London School of Hygiene and Tropical Medicine London UK"},{"name":"Department of Primary Care and Public Health Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Huntley","sequence":"additional","affiliation":[{"name":"Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Post","sequence":"additional","affiliation":[{"name":"Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Rigby","sequence":"additional","affiliation":[{"name":"Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhumita","family":"Shrotri","sequence":"additional","affiliation":[{"name":"Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah V.","family":"Williams","sequence":"additional","affiliation":[{"name":"Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon J.","family":"Peacock","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2020.04.009"},{"key":"e_1_2_8_4_1","article-title":"False\u2010negative results of initial RT\u2010PCR assays for COVID\u201019: a systematic review","author":"Arevalo\u2010Rodriguez I","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_5_1","volume-title":"FebriDx for C\u2010reactive protein and Myxovirus virus resistance protein A testing in primary care: A testing in primary care Medtech innovation briefing","author":"NICE","year":"2017"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Utility of FebriDx in early identification of possible COVID19 infection","author":"Karim N","year":"2020","journal-title":"Res Sq"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.06.051"},{"key":"e_1_2_8_8_1","first-page":"13","article-title":"Diagnostic testing for severe acute respiratory syndrome\u2010related coronavirus\u20102: a narrative review","volume":"13","author":"Cheng MP","year":"2020","journal-title":"Ann Intern Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2196-x"},{"key":"e_1_2_8_10_1","article-title":"Antibody responses to SARS\u2010CoV\u20102 in patients of novel coronavirus disease 2019","volume":"28","author":"Zhao J","year":"2020","journal-title":"Clin Infect Dis"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa310"},{"key":"e_1_2_8_12_1","article-title":"A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease","author":"Huang AT","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-3-17"},{"issue":"2","key":"e_1_2_8_14_1","first-page":"2019","article-title":"Evaluation of the febridx host response point\u2010of\u2010care test to differentiate viral from bacterial etiology in adults hospitalized with acute respiratory illness during influenza season","volume":"6","author":"Beard K","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3402\/ecrj.v2.28245"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6100094"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2018.1474002"},{"key":"e_1_2_8_18_1","unstructured":"FIND.SARS\u2010CoV2 diagnostics: performance data.2020.https:\/\/www.finddx.org\/covid\u201019\/dx\u2010data\/. Accessed June 02 2020."}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Firv.12796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12796","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T10:23:14Z","timestamp":1693650194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/irv.12796"],"URL":"https:\/\/doi.org\/10.1111\/irv.12796","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.12796\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/IRV.12796\/v1\/review1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}