{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:57Z","timestamp":1772160417243,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The longitudinal observation of the detection of antibody responses to SARS\u2010CoV\u20102 using antibody kits during the clinical course of COVID\u201019 is not yet fully investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To understand the significance of the detection of anti\u2010SARS\u2010CoV\u20102 antibodies, particularly IgG, using a rapid antibody kit, during the clinical course of COVID\u201019 patients with different severities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010three serum samples from 18 patients (5 asymptomatic and 13 symptomatic patients) were retrospectively examined using a commercial SARS\u2010CoV\u20102 IgM\/IgG antibody kit. PCR positivity of patient samples was also examined as a marker of current SARS\u2010CoV\u20102 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IgG antibodies were detected in all cases in this study. The IgG detection rates reached 100.0% in samples collected on day 13 or later. IgG seropositivity after an initial negative status was observed in 13 patients (3\/5 asymptomatic and 10\/13 symptomatic cases). Interestingly, the persistence of both PCR and IgG positivity was detected in seven cases, of which three were asymptomatic. The longest overlap duration of the PCR and IgG positivity was 17\u00a0days in asymptomatic status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SARS\u2010CoV\u20102\u2010specific IgG production can be detected in all infected individuals, using a rapid antibody kit, irrespective of clinical status. However, these findings suggest that, in some infected individuals, particularly those with asymptomatic status, the presence of virus\u2010specific IgG antibodies does not imply prompt viral clearance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12802","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T16:08:09Z","timestamp":1601309289000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical significance of SARS\u2010CoV\u20102\u2010specific IgG detection with a rapid antibody kit for COVID\u201019 patients"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8804-3181","authenticated-orcid":false,"given":"Yong","family":"Chong","sequence":"first","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine) Fukuoka 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruriko","family":"Nishida","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine) Fukuoka Japan"},{"name":"Department of Clinical Chemistry and Laboratory Medicine Kyushu University Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-230X","authenticated-orcid":false,"given":"Yoshihiro","family":"Eriguchi","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine) Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Miyake","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine) Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine) Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Nagasaki","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Shimono","sequence":"additional","affiliation":[{"name":"Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences (The First Department of Internal Medicine) Fukuoka Japan"},{"name":"Center for the Study of Global Infection Kyushu University Hospital Fukuoka 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