{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:53:25Z","timestamp":1788926005839,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T00:00:00Z","timestamp":1617494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Seasonal influenza is a burden for emergency departments (ED). The aim of this study was to investigate whether point\u2010of\u2010care (POC) PCR testing can be used to reduce staff sick days and improve diagnostic and therapeutic procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to investigate whether point\u2010of\u2010care (POC) PCR testing can be used to reduce staff sick days and improve diagnostic and therapeutic procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a cross\u2010over design, the cobas\u00ae Liat\u00ae Influenza A\/B POC PCR test (Liat) was compared with standard clinical practice during the 2019\/2020 influenza season. All adult patients (aged\u00a0\u2265\u00a018\u00a0years) with fever (\u226538\u00b0C) and respiratory symptoms were included. Primary end points were the prevalence of influenza infections in the ED and staff sick days. Secondary end points were frequency of antiviral and antibacterial therapy, time between admission and test result or treatment initiation, patient disposition, ED length of stay (LOS), and for inpatients mortality and LOS. Nurses were interviewed about handling and integration of POC testing. The occurrence of SARS\u2010CoV\u20102 infections coincided with the second half of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 828 patients were enrolled in the study. All 375 patients of the intervention group were tested with Liat, and 103 patients of them (27.6%) tested positive. During the intervention period, staff sick days were reduced by 34.4% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.023). Significantly, more patients in the intervention group received antiviral therapy with neuraminidase inhibitors (7.2% vs 3.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.028) and tested patients received antibiotics more frequently (40.0% vs 31.6%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.033). Patients with POC test were transferred to external hospitals significantly more often (5.6% vs 1.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that POC testing for influenza is useful in the ED, especially if it is heavily frequented by patients with respiratory symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12857","type":"journal-article","created":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T23:18:30Z","timestamp":1617578310000},"page":"608-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Point\u2010of\u2010care testing for influenza in a university emergency department: A prospective study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-3251","authenticated-orcid":false,"given":"Benjamin","family":"Perlitz","sequence":"first","affiliation":[{"name":"Emergency and Acute Medicine Campus Virchow Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Slagman","sequence":"additional","affiliation":[{"name":"Emergency and Acute Medicine Campus Virchow Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hitzek","sequence":"additional","affiliation":[{"name":"Emergency and Acute Medicine Campus Virchow Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Riedlinger","sequence":"additional","affiliation":[{"name":"Emergency and Acute Medicine Campus Virchow Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"M\u00f6ckel","sequence":"additional","affiliation":[{"name":"Emergency and Acute Medicine Campus Virchow Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Robert Koch\u2010Institut.Influenza (Teil 1): erkrankungen durch saisonale Influenzaviren\u2010RKI\u2010Ratgeber.2019."},{"key":"e_1_2_9_3_1","first-page":"3","article-title":"Erste ergebnisse zum verlauf der grippewelle in der saison 2019\/20: mit 11 wochen vergleichsweise k\u00fcrzere dauer und eine moderate anzahl an influenza\u2010bedingten arztbesuchen","volume":"16","author":"Goerlitz LDR","year":"2020","journal-title":"Epid Bull"},{"key":"e_1_2_9_4_1","unstructured":"Robert Koch\u2010Institut.Bericht zur Epidemiologie der Influenza in Deutschland Saison. 2018\/19 2019."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-017-1606-z"},{"key":"e_1_2_9_6_1","unstructured":"GBE\u2010Bund.Krankheitskosten in mio. \u20ac f\u00fcr Deutschland. 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