{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:20:51Z","timestamp":1791523251086,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>COVID\u201019 has significant case fatality. Glucocorticoids are the only treatment shown to improve survival, but only among patients requiring supplemental oxygen. WHO advises patients to seek medical care for \u201ctrouble breathing,\u201d but hypoxemic patients frequently have no respiratory symptoms. Our cohort study of hospitalized COVID\u201019 patients shows that respiratory symptoms are uncommon and not associated with mortality. By contrast, objective signs of respiratory compromise\u2014oxygen saturation and respiratory rate\u2014are associated with markedly elevated mortality. Our findings support expanding guidelines to include at\u2010home assessment of oxygen saturation and respiratory rate in order to expedite life\u2010saving treatments patients to high\u2010risk COVID\u201019 patients.<\/jats:p>","DOI":"10.1111\/irv.12869","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T06:17:55Z","timestamp":1621837075000},"page":"569-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Admission respiratory status predicts mortality in COVID\u201019"],"prefix":"10.1111","volume":"15","author":[{"given":"Neal A.","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Rush University Medical Center  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainy J.","family":"Savla","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Rush University Medical Center  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne Michelle D.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Division of Cardiology Rush University Medical Center  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"Du\u2010Fay\u2010de\u2010Lavallaz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Rush University Medical Center  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-1844","authenticated-orcid":false,"given":"Rozenn N.","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"McKnight","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Department of Biostatistics University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-4367","authenticated-orcid":false,"given":"Sina A.","family":"Gharib","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"},{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nona","family":"Sotoodehnia","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Washington  Seattle WA USA"},{"name":"Cardiovascular Health Research Unit University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031304"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030340"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_6_5_1","unstructured":"https:\/\/www.covid19treatmentguidelines.nih.gov\/critical\u2010care\/oxygenation\u2010and\u2010ventilation\/"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280769"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_6_8_1","unstructured":"Centers for Disease Control and Prevention Covid\u201019. Accessed february 12 2021 athttps:\/\/www.Cdc.Gov\/coronavirus\/2019\u2010ncov\/if\u2010you\u2010are\u2010sick\/steps\u2010when\u2010sick.Html. World health organization coronavirus disease (covid\u201019) advice for the public. Accessed february 12 2021 athttps:\/\/www.Who.Int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/advice\u2010for\u2010public"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051936"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2029240"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202005-418FR"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12869","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T23:02:04Z","timestamp":1693263724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/irv.12869"],"URL":"https:\/\/doi.org\/10.1111\/irv.12869","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.12869\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,24]]},"assertion":[{"value":"2021-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}