{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:06:53Z","timestamp":1790791613245,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The hospitalized acute respiratory tract infection (HARTI) study used the Respiratory Intensity and Impact Questionnaire (RiiQ\u2122) Symptom Scale, derived from FluiiQ\u2122, to assess and compare the burden of respiratory infection symptoms for patients with influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) infection, with or without core risk factors (CRF) (age \u226565; chronic heart, renal, obstructive pulmonary disease; asthma).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a prospective cohort study in adult patients hospitalized with acute respiratory tract infection (40 centers, 12 countries) during two consecutive influenza\/RSV\/hMPV seasons (2017\u20132019). The RiiQ\u2122 Symptom Scale and EuroQol 5\u2010Dimensions 5\u2010Levels (EQ\u20105D\u20105L) were assessed by interview at two timepoints during hospitalization and at 1, 2, and 3\u2009months post\u2010discharge.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean lower respiratory tract (LRT) symptom scores were higher for RSV and hMPV participants compared to influenza at 48\u2009h after enrollment\/early discharge (\n p<\/jats:italic>\n \u2009=\u20090.001) and 3\u2009months post\u2010discharge (\n p<\/jats:italic>\n \u2009=\u20090.007). This was driven by LRT symptoms, including shortness of breath (SOB) (\n p<\/jats:italic>\n \u2009<\u20090.01) and wheezing (\n p<\/jats:italic>\n \u2009<\u20090.01) during hospitalization, and SOB (\n p<\/jats:italic>\n \u2009<\u20090.05) and cough (\n p<\/jats:italic>\n \u2009<\u20090.05) post\u2010discharge. Participants with CRF reported more moderate\u2010to\u2010severe SOB (\n p<\/jats:italic>\n \u2009<\u20090.05) and wheezing (\n p<\/jats:italic>\n \u2009<\u20090.05) compared to CRF(\u2212) participants post\u2010discharge. EQ\u20105D\u20105L scores were moderately associated with RiiQ\u2122 LRT and systemic symptoms domains.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Results from the HARTI study suggest that in the study population, LRT symptoms were more severe for RSV and hMPV groups and for patients with CRF. RiiQ\u2122 Symptom Scale scores shows a moderate association with EQ\u20105D\u20105L indicating that the RiiQ\u2122 may provide useful insights and offer advantages over other measures for use in interventional RSV adult clinical studies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/irv.12903","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:13:11Z","timestamp":1630563191000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post\u2010discharge assessed by Respiratory Intensity and Impact Questionnaire"],"prefix":"10.1111","volume":"16","author":[{"given":"Ann R.","family":"Falsey","sequence":"first","affiliation":[{"name":"School of Medicine Rochester Regional Health University of Rochester Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Walsh","sequence":"additional","affiliation":[{"name":"School of Medicine Rochester Regional Health University of Rochester Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Department of Health and Medical Sciences Swinburne University of Technology Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Vandendijck","sequence":"additional","affiliation":[{"name":"Janssen Infectious Diseases Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Ren","sequence":"additional","affiliation":[{"name":"Janssen Infectious Diseases Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Witek","sequence":"additional","affiliation":[{"name":"Janssen Research & Development, LLC Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diye","family":"Kang","sequence":"additional","affiliation":[{"name":"Janssen Infectious Diseases Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chan","sequence":"additional","affiliation":[{"name":"Janssen Global Services, LLC Raritan New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Scott","sequence":"additional","affiliation":[{"name":"Janssen Global Services, LLC Raritan New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Ispas","sequence":"additional","affiliation":[{"name":"Janssen Infectious Diseases Beerse Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.12.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2019.09.2747"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz059"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy991"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix503"},{"key":"e_1_2_10_8_1","first-page":"S1","article-title":"Abstract: PIN129. Adapting influenza patient\u2010reported outcomes (PRO) measures to monitor respiratory syncytial virus (RSV) symptom severity in adults: qualitative evidence of key concepts and content validity","author":"Scott J","year":"2018","journal-title":"Value in Health"},{"key":"e_1_2_10_9_1","article-title":"Psychometric evaluation of the respiratory infection intensity and IMPACT Questionnaire Version 2 (RIIQV2) symptom scores for respiratorysyncytial VIRUS","author":"Osborne R","year":"2021","journal-title":"Virtual ISPOR"},{"key":"e_1_2_10_10_1","unstructured":"FalseyAR.Global study of adults hospitalized with influenza respiratory syncytial virus (RSV) and human metapneumovirus (hMPV): risk factors clinical characteristics and outcomes. paper presented at: The Seventh ESWI Influenza Conference2020; Virtual Edition."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.04.020"},{"key":"e_1_2_10_12_1","unstructured":"EQ\u20105D\u20105L|About.EQ\u20105D Web site.https:\/\/euroqol.org\/eq-5d-instruments\/eq-5d-5l-about\/. Published 2021. Accessed 29 April 2021."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00569.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.02.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2019.24.45.1900140"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207782"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T08:17:17Z","timestamp":1692605837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/irv.12903"],"URL":"https:\/\/doi.org\/10.1111\/irv.12903","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.12903\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"2021-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}