{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:28:00Z","timestamp":1790800080839,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The declaration of Coronavirus disease 2019 (COVID\u201019) as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 required rapid implementation of early investigations to inform appropriate national and global public health actions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The suite of existing pandemic preparedness generic epidemiological early investigation protocols was rapidly adapted for COVID\u201019, branded the \u2018UNITY studies\u2019 and promoted globally for the implementation of standardized and quality studies. Ten protocols were developed investigating household (HH) transmission, the first few cases (FFX), population seroprevalence (SEROPREV), health facilities transmission (n\u2009=\u20092), vaccine effectiveness (n\u2009=\u20092), pregnancy outcomes and transmission, school transmission, and surface contamination. Implementation was supported by WHO and its partners globally, with emphasis to support building surveillance and research capacities in low\u2010 and middle\u2010income countries (LMIC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>WHO generic protocols were rapidly developed and published on the WHO website, 5\/10 protocols within the first 3\u00a0months of the response. As of 30 June 2021, 172 investigations were implemented by 97 countries, of which 62 (64%) were LMIC. The majority of countries implemented population seroprevalence (71 countries) and first few cases\/household transmission (37 countries) studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The widespread adoption of UNITY protocols across all WHO regions indicates that they addressed subnational and national needs to support local public health decision\u2010making to prevent and control the pandemic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12915","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T05:36:09Z","timestamp":1633671369000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Early epidemiological investigations: World Health Organization UNITY protocols provide a standardized and timely international investigation framework during the COVID\u201019 pandemic"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-1753","authenticated-orcid":false,"given":"Isabel","family":"Bergeri","sequence":"first","affiliation":[{"name":"WHO Health Emergencies Programme World Health Organization Headquarters  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-3943","authenticated-orcid":false,"given":"Hannah C.","family":"Lewis","sequence":"additional","affiliation":[{"name":"WHO Health Emergencies Programme World Health Organization Headquarters  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-575X","authenticated-orcid":false,"given":"Lorenzo","family":"Subissi","sequence":"additional","affiliation":[{"name":"WHO Health Emergencies Programme World Health Organization Headquarters  Geneva 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