{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:17:19Z","timestamp":1784888239237,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009041","name":"National Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We describe epidemiology and outcomes of confirmed SARS\u2010CoV\u20102 infection and positive admissions among children &lt;18\u2009years in South Africa, an upper\u2010middle income setting with high inequality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Laboratory and hospital COVID\u201019 surveillance data, 28 January \u2010 19 September 2020 was used. Testing rates were calculated as number of tested for SARS\u2010CoV\u20102 divided by population at risk; test positivity rates were calculated as positive tests divided by total number of tests. In\u2010hospital case fatality ratio (CFR) was calculated based on hospitalized positive admissions with outcome data who died in\u2010hospital and whose death was judged SARS\u2010CoV\u20102 related by attending physician.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>315\u2009570 children aged &lt;18\u2009years were tested for SARS\u2010CoV\u20102; representing 8.9% of all 3\u2009548\u2009738 tests and 1.6% of all children in the country. Of children tested, 46\u2009137 (14.6%) were positive. Children made up 2.9% (n\u2009=\u00a02007) of all SARS\u2010CoV\u20102 positive admissions to sentinel hospitals. Among children, 47 died (2.6% case\u2010fatality). In\u2010hospital deaths were associated with male sex [adjusted odds ratio (aOR) 2.18 (95% confidence intervals [CI] 1.08\u20134.40)] vs female; age &lt;1\u00a0year [aOR 4.11 (95% CI 1.08\u201315.54)], age 10\u201314\u2009years [aOR 4.20 (95% CI1.07\u201316.44)], age 15\u201317\u2009years [aOR 4.86 (95% 1.28\u201318.51)] vs age 1\u20134\u00a0years; admission to a public hospital [aOR 5.07(95% 2.01\u201312.76)] vs private hospital and \u22651 underlying conditions [aOR 12.09 (95% CI 4.19\u201334.89)] vs none.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with underlying conditions were at greater risk of severe SARS\u2010CoV\u20102 outcomes. Children &gt; 10\u00a0years, those in certain provinces and those with underlying conditions should be considered for increased testing and vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12916","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T01:45:39Z","timestamp":1637286339000},"page":"34-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiology of SARS\u2010CoV\u20102 infection and SARS\u2010CoV\u20102 positive hospital admissions among children in South Africa"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-616X","authenticated-orcid":false,"given":"Tendesayi","family":"Kufa","sequence":"first","affiliation":[{"name":"National Institute for Communicable Diseases National Health Laboratory Services  Johannesburg South Africa"},{"name":"School of Public Health University of the Witwatersrand  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