{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:55Z","timestamp":1772160415995,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI144616\u201002S1"],"award-info":[{"award-number":["U01AI144616\u201002S1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Influenza Resp Viruses"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age and obesity status are associated with severe outcomes among hospitalized individuals with COVID\u201019. It remains unclear whether age and obesity are risk factors for milder COVID\u201019 illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled SARS\u2010CoV\u20102\u2010exposed individuals. Participants recorded symptoms for 28\u2009days and were tested for SARS\u2010CoV\u20102 by reverse transcription polymerase chain reaction (RT\u2010PCR) and serology. Type, number, and duration of symptoms and SARS\u2010CoV\u20102 laboratory parameters were compared by age and obesity status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 552 individuals enrolled from June 2020 to January 2021, 470 (85.1%) tested positive for SARS\u2010CoV\u20102 including 261 (55.5%) adults \u226518\u2009years, 61 (13.0%) adolescents 12\u201317\u2009years, and 148 (31.5%) children &lt;12\u2009years. Children had fewer symptoms (median 2 vs. 3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) lasting fewer days (median 5 vs. 7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with adolescents\/adults. Body mass index of 300 (63.8%) individuals classified with overweight or obesity (OWOB). Individuals with OWOB suffered more symptoms compared with individuals without OWOB (median 3 vs. 2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037), including more cough and shortness of breath (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023 and 0.026, respectively). Adolescents with OWOB were more likely to be symptomatic (66.7% vs. 34.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and have longer respiratory symptoms (median 7 vs. 4\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) compared with adolescents without OWOB. Lower RT\u2010PCR Ct values were found in children and symptomatic individuals compared with adolescent and adults and asymptomatic individuals, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001 and 0.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adolescents and adults with OWOB experience more respiratory symptoms from COVID\u201019 despite similar viral loads. These findings underscore the importance of vaccinating individuals with OWOB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/irv.12918","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T07:41:30Z","timestamp":1634802090000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical manifestations of COVID\u201019 differ by age and obesity status"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-8556","authenticated-orcid":false,"given":"Wesley A.","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Turner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Marentes Ruiz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa L.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-7349","authenticated-orcid":false,"given":"Zion","family":"Congrave\u2010Wilson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaycee","family":"Jumarang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Perez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Peralta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-0933","authenticated-orcid":false,"given":"Pia S.","family":"Pannaraj","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Department of Pediatrics and Molecular Microbiology and Immunology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1467"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7010e4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7003e1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7023e1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.2430"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1326-2125"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011086117"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154373"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6950e2"},{"key":"e_1_2_10_12_1","unstructured":"National Institutes of Health.Anti\u2010SARS\u2010CoV\u20102 monoclonal antibodies August 4 20212021. Available at:https:\/\/www.covid19treatmentguidelines.nih.gov\/therapies\/anti\u2010sars\u2010cov\u20102\u2010antibody\u2010products\/anti\u2010sars\u2010cov\u20102\u2010monoclonal\u2010antibodies\/. Accessed August 27 2021."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e3"},{"key":"e_1_2_10_14_1","first-page":"1","article-title":"Clinical features of COVID\u201019 in newborns, infants, and children: a systematic review and meta\u2010analysis","author":"Taheri L","year":"2021","journal-title":"Compr Child Adolesc Nurs"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.11.016"},{"key":"e_1_2_10_16_1","unstructured":"Centers for Disease Control and Prevention.Healthy weight nutrition and physical activity September 17 2020. Available at:https:\/\/www.cdc.gov\/healthyweight\/assessing\/index.html. 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