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Two\u2010dose VE against laboratory\u2010confirmed SARS\u2010CoV\u20102 infection (symptomatic and asymptomatic) was estimated using Cox proportional hazards models with time\u2010varying vaccination status in a prospective rural community cohort of 1266 participants aged\u2009\u226512\u2009years. Between November 3, 2020 and December 7, 2021, VE was 56% for mRNA COVID\u201019 vaccines overall, 65% for Moderna, and 50% for Pfizer\u2010BioNTech. VE when Delta predominated (June to December 2021) was 54% for mRNA COVID\u201019 vaccines overall, 59% for Moderna, and 52% for Pfizer\u2010BioNTech.<\/jats:p>","DOI":"10.1111\/irv.12970","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T04:39:54Z","timestamp":1645159194000},"page":"607-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["mRNA COVID\u201019 vaccine effectiveness against SARS\u2010CoV\u20102 infection in a prospective community cohort, rural Wisconsin, November 2020 to December 2021"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-6439","authenticated-orcid":false,"given":"Huong Q.","family":"McLean","sequence":"first","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-7190","authenticated-orcid":false,"given":"David L.","family":"McClure","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-1378","authenticated-orcid":false,"given":"Jennifer P.","family":"King","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Meece","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-8203","authenticated-orcid":false,"given":"David","family":"Pattinson","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-1775","authenticated-orcid":false,"given":"Gabriele","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-8296","authenticated-orcid":false,"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-9941","authenticated-orcid":false,"given":"Melissa A.","family":"Rolfes","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-0415","authenticated-orcid":false,"given":"Edward A.","family":"Belongia","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"International Vaccine Access Center (IVAC) Results of COVID\u201019 vaccine effectiveness studies: an ongoing systematic review weekly summary tables.2021 Johns Hopkins Bloomberg School of Public Health and World Health Organization. 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Accessed October 11 2020.https:\/\/rupri.public-health.uiowa.edu\/publications\/policybriefs\/2021\/COVID%20Vaccinations%20and%20Cases.pdf"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab640"}],"container-title":["Influenza and Other Respiratory Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12970","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/irv.12970","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/irv.12970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:02:08Z","timestamp":1692828128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/irv.12970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/irv.12970"],"URL":"https:\/\/doi.org\/10.1111\/irv.12970","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/IRV.12970\/v1\/decision1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.14.21267809","asserted-by":"object"}]},"ISSN":["1750-2640","1750-2659"],"issn-type":[{"value":"1750-2640","type":"print"},{"value":"1750-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,18]]},"assertion":[{"value":"2022-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}